Crystal polymorphism as a probe for molecular self-assembly during nucleation from solutions: the case of 2,6-dihydroxybenzoic acid

Research output: Contribution to journalArticle

  • External authors:
  • N. Blagden
  • S. Righini
  • H. Alison
  • M. J. Quayle
  • S. Fuller


The relationship between molecular self-assembly processes and nucleation during crystallization from solution is an important issue, both in terms of fundamental physical chemistry and for the control and application of crystallization processes in crystal engineering and materials chemistry. This contribution examines the extent to which the occurrence of crystal polymorphism can be used as an indicator of the nature of molecular aggregation processes in supersaturated solutions. For the specific case of 2,6-dihydroxybenzoic acid a combination of solubility, spectroscopic, crystallization, and molecular modeling techniques are used to demonstrate that there is a direct link between the solvent-induced self-assembly of this molecule and the relative occurrence of its two polymorphic forms from toluene and chloroform solutions. © 2001 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)59-65
Number of pages6
JournalCrystal Growth and Design
Issue number1
Publication statusPublished - 2001