Critique of the two-fold measure of prediction success for ratios: Application for the assessment of drug-drug interactions

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Current assessment of drug-drug interaction (DDI) prediction success is based on whether predictions fall within a two-fold range of the observed data. This strategy results in a potential bias toward successful prediction at lower interaction levels [ratio of the area under the concentration-time profile (AUC) in the presence of inhibitor/ inducer compared with control is

Bibliographical metadata

Original languageEnglish
Pages (from-to)170-173
Number of pages3
JournalDrug Metabolism and Disposition
Issue number2
Publication statusPublished - Feb 2011