Cost-effectiveness of first- v. second-generation antipsychotic drugs: Results from a randomised controlled trial in schizophrenia responding poorly to previous therapy

Research output: Contribution to journalArticle

  • External authors:
  • Peter B. Jones
  • Thomas R E Barnes
  • Fiona Gaughran
  • Alison Markwick
  • Helen Lloyd


Background: There are claims that the extra costs of atypical (second-generation) antipsychotic drugs over conventional (first-generation) drugs are offset by improved health-related quality of life. Aims: To determine the relative costs and value of treatment with conventional or atypical antipsychotics in people with schizophrenia. Method: Cost-effectiveness acceptability analysis integrated clinical and economic randomised controlled trial data of conventional and atypical antipsychotics in routine practice. Results: Conventional antipsychotics had lower costs and higher quality-adjusted life-years (QALYs) than atypical antipsychotics and were more than 50% likely to be cost-effective. Conclusions: The primary and sensitivity analyses indicated that conventional antipsychotics may be cost-saving and associated with a gain in QALYs compared with atypical antipsychotics.

Bibliographical metadata

Original languageEnglish
Pages (from-to)14-22
Number of pages8
JournalBritish Journal of Psychiatry
Issue numberJULY
Publication statusPublished - Jul 2007

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