Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression

Research output: Contribution to journalArticle

  • External authors:
  • Kyu Man Han
  • Sunyoung Choi
  • Kyoung Sae Na
  • Ho Kyoung Yoon
  • Min Soo Lee
  • Byung Joo Ham

Abstract

Background The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naïve MDD patients and healthy controls. Methods Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n=20) were enrolled in this study and were compared to age-, sex-, and education level-matched healthy controls (n=22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRI). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups. Results The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P

Bibliographical metadata

Original languageEnglish
Pages (from-to)42-48
Number of pages6
JournalJournal of Affective Disorders
Volume155
Issue number1
DOIs
Publication statusPublished - Feb 2014