Continuous-flow synthesis of trimethylsilylphenyl perfluorosulfonate benzyne precursors

Research output: Contribution to journalArticle


2-(Trimethylsilyl)phenyl perfluorosulfonated aryne precursors may now be accessed using flow chemistry, enabling the fast preparation of pure compounds with no requirement for low temperature lithiation or column chromatography. The process has been adapted to novel nonaflate precursors, utilizing the cheaper and more user-friendly nonaflyl fluoride reagent. The resultant nonaflates are shown to successfully participate in a range of aryne reaction classes. © 2014 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2684-2687
Number of pages3
JournalOrganic Letters
Issue number10
StatePublished - 16 May 2014