Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCTCitation formats

  • External authors:
  • Eva Versteijne
  • Oliver J. Gurney-Champion
  • Astrid van der Horst
  • Eelco Lens
  • M. Willemijn Kolff
  • Jeroen Buijsen
  • Gati Ebrahimi
  • Karen J. Neelis
  • Coen R N Rasch
  • Jaap Stoker
  • Arjan Bel
  • Geertjan van Tienhoven

Standard

Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT : A multi-institutional study. / Versteijne, Eva; Gurney-Champion, Oliver J.; van der Horst, Astrid; Lens, Eelco; Kolff, M. Willemijn; Buijsen, Jeroen; Ebrahimi, Gati; Neelis, Karen J.; Rasch, Coen R N; Stoker, Jaap; van Herk, Marcel; Bel, Arjan; van Tienhoven, Geertjan.

In: Practical Radiation Oncology , Vol. 12, No. 1, 58, 23.03.2017, p. 58.

Research output: Contribution to journalArticle

Harvard

Versteijne, E, Gurney-Champion, OJ, van der Horst, A, Lens, E, Kolff, MW, Buijsen, J, Ebrahimi, G, Neelis, KJ, Rasch, CRN, Stoker, J, van Herk, M, Bel, A & van Tienhoven, G 2017, 'Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: A multi-institutional study', Practical Radiation Oncology , vol. 12, no. 1, 58, pp. 58. https://doi.org/10.1186/s13014-017-0777-0

APA

Versteijne, E., Gurney-Champion, O. J., van der Horst, A., Lens, E., Kolff, M. W., Buijsen, J., ... van Tienhoven, G. (2017). Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: A multi-institutional study. Practical Radiation Oncology , 12(1), 58. [58]. https://doi.org/10.1186/s13014-017-0777-0

Vancouver

Versteijne E, Gurney-Champion OJ, van der Horst A, Lens E, Kolff MW, Buijsen J et al. Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: A multi-institutional study. Practical Radiation Oncology . 2017 Mar 23;12(1):58. 58. https://doi.org/10.1186/s13014-017-0777-0

Author

Versteijne, Eva ; Gurney-Champion, Oliver J. ; van der Horst, Astrid ; Lens, Eelco ; Kolff, M. Willemijn ; Buijsen, Jeroen ; Ebrahimi, Gati ; Neelis, Karen J. ; Rasch, Coen R N ; Stoker, Jaap ; van Herk, Marcel ; Bel, Arjan ; van Tienhoven, Geertjan. / Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT : A multi-institutional study. In: Practical Radiation Oncology . 2017 ; Vol. 12, No. 1. pp. 58.

Bibtex

@article{c06f4c2078e44fba82ed2f0a8e04bb76,
title = "Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: A multi-institutional study",
abstract = "Background: The delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT. Methods: Eight observers (radiation oncologists) from six institutions delineated pancreatic tumors of four patients with (borderline) resectable pancreatic cancer. The study consisted of two stages. In the 3DCT-stage, the gross tumor volume (GTV) was delineated on a contrast-enhanced scan. In the 4DCT-stage, the internal GTV (iGTV) was delineated, accounting for the respiratory motion. We calculated the volumes of the (i)GTV, the overlap of the delineated volumes (expressed as generalized conformity index: CIgen), the local observer variation (local standard deviation: SD) and the overall observer variation (overall SD). We compared these results between GTVs and iGTVs. Additionally, observers were asked to fill out a questionnaire concerning the difficulty of the delineation and their experience in delineating pancreatic tumors. Results: The ratios of the largest to the smallest delineated GTV and iGTV within the same patient were 6.8 and 16.5, respectively. As the iGTV incorporates the GTV during all respiratory phases, the mean volumes of the iGTV (40.07 cm3) were larger than those of the GTV (29.91 cm3). For all patients, CIgen was larger for the iGTV than for the GTV. The mean overall observer variation (root-mean-square of all local SDs over four patients) was 0.63 cm and 0.80 cm for GTV and iGTV, respectively. The largest local observer variations were seen close to biliary stents and suspicious pathological enlarged lymph nodes, as some observers included them and some did not. This variation was more pronounced for the iGTV than for the GTV. The observers rated the 3DCT-stage and 4DCT-stage equally difficult and treated on average three to four pancreatic cancer patients per year. Conclusions: A considerable interobserver variation in delineation of pancreatic tumors was observed. This variation was larger for 4D than for 3D delineation. The largest local observer variation was found around biliary stents and suspicious pathological enlarged lymph nodes.",
keywords = "Delineation, Interobserver variation, Pancreatic cancer",
author = "Eva Versteijne and Gurney-Champion, {Oliver J.} and {van der Horst}, Astrid and Eelco Lens and Kolff, {M. Willemijn} and Jeroen Buijsen and Gati Ebrahimi and Neelis, {Karen J.} and Rasch, {Coen R N} and Jaap Stoker and {van Herk}, Marcel and Arjan Bel and {van Tienhoven}, Geertjan",
year = "2017",
month = "3",
day = "23",
doi = "10.1186/s13014-017-0777-0",
language = "English",
volume = "12",
pages = "58",
journal = "Practical Radiation Oncology",
issn = "1879-8500",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT

T2 - A multi-institutional study

AU - Versteijne, Eva

AU - Gurney-Champion, Oliver J.

AU - van der Horst, Astrid

AU - Lens, Eelco

AU - Kolff, M. Willemijn

AU - Buijsen, Jeroen

AU - Ebrahimi, Gati

AU - Neelis, Karen J.

AU - Rasch, Coen R N

AU - Stoker, Jaap

AU - van Herk, Marcel

AU - Bel, Arjan

AU - van Tienhoven, Geertjan

PY - 2017/3/23

Y1 - 2017/3/23

N2 - Background: The delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT. Methods: Eight observers (radiation oncologists) from six institutions delineated pancreatic tumors of four patients with (borderline) resectable pancreatic cancer. The study consisted of two stages. In the 3DCT-stage, the gross tumor volume (GTV) was delineated on a contrast-enhanced scan. In the 4DCT-stage, the internal GTV (iGTV) was delineated, accounting for the respiratory motion. We calculated the volumes of the (i)GTV, the overlap of the delineated volumes (expressed as generalized conformity index: CIgen), the local observer variation (local standard deviation: SD) and the overall observer variation (overall SD). We compared these results between GTVs and iGTVs. Additionally, observers were asked to fill out a questionnaire concerning the difficulty of the delineation and their experience in delineating pancreatic tumors. Results: The ratios of the largest to the smallest delineated GTV and iGTV within the same patient were 6.8 and 16.5, respectively. As the iGTV incorporates the GTV during all respiratory phases, the mean volumes of the iGTV (40.07 cm3) were larger than those of the GTV (29.91 cm3). For all patients, CIgen was larger for the iGTV than for the GTV. The mean overall observer variation (root-mean-square of all local SDs over four patients) was 0.63 cm and 0.80 cm for GTV and iGTV, respectively. The largest local observer variations were seen close to biliary stents and suspicious pathological enlarged lymph nodes, as some observers included them and some did not. This variation was more pronounced for the iGTV than for the GTV. The observers rated the 3DCT-stage and 4DCT-stage equally difficult and treated on average three to four pancreatic cancer patients per year. Conclusions: A considerable interobserver variation in delineation of pancreatic tumors was observed. This variation was larger for 4D than for 3D delineation. The largest local observer variation was found around biliary stents and suspicious pathological enlarged lymph nodes.

AB - Background: The delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT. Methods: Eight observers (radiation oncologists) from six institutions delineated pancreatic tumors of four patients with (borderline) resectable pancreatic cancer. The study consisted of two stages. In the 3DCT-stage, the gross tumor volume (GTV) was delineated on a contrast-enhanced scan. In the 4DCT-stage, the internal GTV (iGTV) was delineated, accounting for the respiratory motion. We calculated the volumes of the (i)GTV, the overlap of the delineated volumes (expressed as generalized conformity index: CIgen), the local observer variation (local standard deviation: SD) and the overall observer variation (overall SD). We compared these results between GTVs and iGTVs. Additionally, observers were asked to fill out a questionnaire concerning the difficulty of the delineation and their experience in delineating pancreatic tumors. Results: The ratios of the largest to the smallest delineated GTV and iGTV within the same patient were 6.8 and 16.5, respectively. As the iGTV incorporates the GTV during all respiratory phases, the mean volumes of the iGTV (40.07 cm3) were larger than those of the GTV (29.91 cm3). For all patients, CIgen was larger for the iGTV than for the GTV. The mean overall observer variation (root-mean-square of all local SDs over four patients) was 0.63 cm and 0.80 cm for GTV and iGTV, respectively. The largest local observer variations were seen close to biliary stents and suspicious pathological enlarged lymph nodes, as some observers included them and some did not. This variation was more pronounced for the iGTV than for the GTV. The observers rated the 3DCT-stage and 4DCT-stage equally difficult and treated on average three to four pancreatic cancer patients per year. Conclusions: A considerable interobserver variation in delineation of pancreatic tumors was observed. This variation was larger for 4D than for 3D delineation. The largest local observer variation was found around biliary stents and suspicious pathological enlarged lymph nodes.

KW - Delineation

KW - Interobserver variation

KW - Pancreatic cancer

U2 - 10.1186/s13014-017-0777-0

DO - 10.1186/s13014-017-0777-0

M3 - Article

C2 - 28335780

AN - SCOPUS:85016160858

VL - 12

SP - 58

JO - Practical Radiation Oncology

JF - Practical Radiation Oncology

SN - 1879-8500

IS - 1

M1 - 58

ER -