Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines

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Abstract

A cross-dehydrogenative coupling process has been developed involving the enzymatic oxidation of tetrahydroisoquinolines (THIQ) together with gold-catalyzed C–C bond-formation. The transformation demonstrates the compatibility of gold-mediated chemocatalysis and monoamine oxidase biocatalysis which act co-operatively in one vessel. A range of N-alkyl THIQs were functionalized in this manner at C-(1) position in high yields.

Bibliographical metadata

Original languageEnglish
Pages (from-to)10032-10035
JournalACS Catalysis
Volume8
Issue number11
Early online date21 Sep 2018
DOIs
Publication statusPublished - 2 Nov 2018

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