Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malariaCitation formats

  • External authors:
  • Valentina Barrera
  • Patrick Strangward
  • Elizabeth Attree
  • Steve Kamiza
  • Karl Seydel
  • Terrie Taylor
  • Dan Milner
  • Alister Craig

Standard

Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria. / Barrera, Valentina; Haley, Michael; Strangward, Patrick; Attree, Elizabeth; Kamiza, Steve; Seydel, Karl; Taylor, Terrie; Milner, Dan; Craig, Alister; Couper, Kevin.

In: Frontiers in Immunology, 10.07.2019.

Research output: Contribution to journalArticle

Harvard

Barrera, V, Haley, M, Strangward, P, Attree, E, Kamiza, S, Seydel, K, Taylor, T, Milner, D, Craig, A & Couper, K 2019, 'Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria', Frontiers in Immunology.

APA

Barrera, V., Haley, M., Strangward, P., Attree, E., Kamiza, S., Seydel, K., ... Couper, K. (Accepted/In press). Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria. Frontiers in Immunology.

Vancouver

Barrera V, Haley M, Strangward P, Attree E, Kamiza S, Seydel K et al. Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria. Frontiers in Immunology. 2019 Jul 10.

Author

Barrera, Valentina ; Haley, Michael ; Strangward, Patrick ; Attree, Elizabeth ; Kamiza, Steve ; Seydel, Karl ; Taylor, Terrie ; Milner, Dan ; Craig, Alister ; Couper, Kevin. / Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria. In: Frontiers in Immunology. 2019.

Bibtex

@article{a9635bd36bec41d197dbb087a856df85,
title = "Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria",
abstract = "CD8+ T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human cerebral malaria (HCM) remains unclear. Thus, in this study we have provided the first direct contrast of the accumulation of CD8+ T cells in the brain during HCM and ECM. HCM cases were from children who died of Plasmodium falciparum cerebral malaria at Queen Elizabeth Central Hospital (Malawi) between 2003 and 2010. ECM was induced by infecting C57BL/6J mice with P. berghei ANKA. We demonstrate similarities in the intracerebral CD8+ T cell responses in ECM and HCM, in particular an apparent shared choroid plexus – meningeal route of CD8+ T cell accumulation in the brain. Nevertheless, we also reveal some potentially important differences in compartmentalisation of CD8+ T cells within the cerebrovascular bed in HCM and ECM.",
keywords = "cerebral malaria, CD8+ T cells, brain, Plasmodium falciparum, Plasmodium berghei",
author = "Valentina Barrera and Michael Haley and Patrick Strangward and Elizabeth Attree and Steve Kamiza and Karl Seydel and Terrie Taylor and Dan Milner and Alister Craig and Kevin Couper",
year = "2019",
month = "7",
day = "10",
language = "English",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria

AU - Barrera, Valentina

AU - Haley, Michael

AU - Strangward, Patrick

AU - Attree, Elizabeth

AU - Kamiza, Steve

AU - Seydel, Karl

AU - Taylor, Terrie

AU - Milner, Dan

AU - Craig, Alister

AU - Couper, Kevin

PY - 2019/7/10

Y1 - 2019/7/10

N2 - CD8+ T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human cerebral malaria (HCM) remains unclear. Thus, in this study we have provided the first direct contrast of the accumulation of CD8+ T cells in the brain during HCM and ECM. HCM cases were from children who died of Plasmodium falciparum cerebral malaria at Queen Elizabeth Central Hospital (Malawi) between 2003 and 2010. ECM was induced by infecting C57BL/6J mice with P. berghei ANKA. We demonstrate similarities in the intracerebral CD8+ T cell responses in ECM and HCM, in particular an apparent shared choroid plexus – meningeal route of CD8+ T cell accumulation in the brain. Nevertheless, we also reveal some potentially important differences in compartmentalisation of CD8+ T cells within the cerebrovascular bed in HCM and ECM.

AB - CD8+ T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human cerebral malaria (HCM) remains unclear. Thus, in this study we have provided the first direct contrast of the accumulation of CD8+ T cells in the brain during HCM and ECM. HCM cases were from children who died of Plasmodium falciparum cerebral malaria at Queen Elizabeth Central Hospital (Malawi) between 2003 and 2010. ECM was induced by infecting C57BL/6J mice with P. berghei ANKA. We demonstrate similarities in the intracerebral CD8+ T cell responses in ECM and HCM, in particular an apparent shared choroid plexus – meningeal route of CD8+ T cell accumulation in the brain. Nevertheless, we also reveal some potentially important differences in compartmentalisation of CD8+ T cells within the cerebrovascular bed in HCM and ECM.

KW - cerebral malaria

KW - CD8+ T cells

KW - brain

KW - Plasmodium falciparum

KW - Plasmodium berghei

M3 - Article

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

ER -