Cognition in children with Neurofibromatosis type 1: Data from a Population-based study

Research output: Contribution to journalArticle

  • External authors:
  • Annukka Lehtonen
  • D Trump
  • SM Huson


Aim This study aimed to investigate the core cognitive deficits in children with neurofibromatosis type 1 (NF1). Method The study recruited 49 children with NF1 (25 males, 24 females; mean age 11y 9mo [SD 3y 2mo]), 19 healthy siblings of children with NF1 (sibling comparisons; mean age 12y 7mo [SD 2y 7mo], 9 males, 10 females) and 29 healthy children from the community (community comparisons; mean age 11y [SD 2y 7mo], 12 males, 17 females). Participants completed a battery of cognitive tests including tests of intelligence, academic achievement, attention, visuoperceptual functioning, visual learning, executive functioning, and non-verbal working memory tests. Results Our study, using a population-based sample, confirmed previous findings from studies using variable sampling methods. Children with NF1 had significantly lower Full-scale IQs (p=0.04) and lower academic achievement (p=0.026–0.005) than their siblings. Compared with their siblings, they also had significantly poorer visuospatial processing (p=0.007), visual associate learning (p=0.014), non-verbal working memory (p=0.023), and executive function (p

Bibliographical metadata

Original languageEnglish
Pages (from-to)645-651
Number of pages6
JournalWiley Interdisciplinary Reviews. Cognitive Science (Online)
Issue number7
Publication statusPublished - 2015