Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A reviewCitation formats

  • External authors:
  • P. Silva
  • J. J. Homer
  • N. J. Slevin
  • B. T. Musgrove
  • P. Sloan
  • P. Price

Standard

Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review. / Silva, P.; Homer, J. J.; Slevin, N. J.; Musgrove, B. T.; Sloan, P.; Price, P.; West, C. M L.

In: Clinical Otolaryngology, Vol. 32, No. 5, 10.2007, p. 337-345.

Research output: Contribution to journalArticlepeer-review

Harvard

Silva, P, Homer, JJ, Slevin, NJ, Musgrove, BT, Sloan, P, Price, P & West, CML 2007, 'Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review', Clinical Otolaryngology, vol. 32, no. 5, pp. 337-345. https://doi.org/10.1111/j.1749-4486.2007.01544.x

APA

Silva, P., Homer, J. J., Slevin, N. J., Musgrove, B. T., Sloan, P., Price, P., & West, C. M. L. (2007). Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review. Clinical Otolaryngology, 32(5), 337-345. https://doi.org/10.1111/j.1749-4486.2007.01544.x

Vancouver

Silva P, Homer JJ, Slevin NJ, Musgrove BT, Sloan P, Price P et al. Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review. Clinical Otolaryngology. 2007 Oct;32(5):337-345. https://doi.org/10.1111/j.1749-4486.2007.01544.x

Author

Silva, P. ; Homer, J. J. ; Slevin, N. J. ; Musgrove, B. T. ; Sloan, P. ; Price, P. ; West, C. M L. / Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review. In: Clinical Otolaryngology. 2007 ; Vol. 32, No. 5. pp. 337-345.

Bibtex

@article{294f87e122884572959b787935be2ee1,
title = "Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review",
abstract = "Objective: The main aim of this article was to review the clinical and biological factors that have been shown to influence the response of the head and neck squamous cell carcinoma (HNSCC) to primary radiotherapy and briefly discuss how some of these factors could be exploited to improve outcome. Design: Medline based search covering 1982-2006 to identify the HNSCC literature where the effect of clinical and biological factors on locoregional control and overall survival were investigated. Results: Clinical factors are routinely used in management decisions. Nevertheless, identically staged tumours receiving the same treatment may have different outcomes. Biological factors such as hypoxia, proliferation and radio-sensitivity play an important role in radiation response. However, these are not currently used in practise because tests that are clinically reliable and feasible are not available. Conclusion: High-quality translational research will allow us to develop biological tests that can be used in routine clinical practise to tailor individual treatment, with the ability to improve patient outcome further by modifying the underlying tumour biology. {\textcopyright} 2007 The Authors.",
keywords = "metabolism: Carcinoma, Squamous Cell, radiation effects: Cell Hypoxia, radiation effects: Cell Proliferation, Dose-Response Relationship, Radiation, metabolism: Head and Neck Neoplasms, Humans, metabolism: Tumor Markers, Biological",
author = "P. Silva and Homer, {J. J.} and Slevin, {N. J.} and Musgrove, {B. T.} and P. Sloan and P. Price and West, {C. M L}",
year = "2007",
month = oct,
doi = "10.1111/j.1749-4486.2007.01544.x",
language = "English",
volume = "32",
pages = "337--345",
journal = "Clinical Otolaryngology",
issn = "1749-4478",
publisher = "John Wiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: A review

AU - Silva, P.

AU - Homer, J. J.

AU - Slevin, N. J.

AU - Musgrove, B. T.

AU - Sloan, P.

AU - Price, P.

AU - West, C. M L

PY - 2007/10

Y1 - 2007/10

N2 - Objective: The main aim of this article was to review the clinical and biological factors that have been shown to influence the response of the head and neck squamous cell carcinoma (HNSCC) to primary radiotherapy and briefly discuss how some of these factors could be exploited to improve outcome. Design: Medline based search covering 1982-2006 to identify the HNSCC literature where the effect of clinical and biological factors on locoregional control and overall survival were investigated. Results: Clinical factors are routinely used in management decisions. Nevertheless, identically staged tumours receiving the same treatment may have different outcomes. Biological factors such as hypoxia, proliferation and radio-sensitivity play an important role in radiation response. However, these are not currently used in practise because tests that are clinically reliable and feasible are not available. Conclusion: High-quality translational research will allow us to develop biological tests that can be used in routine clinical practise to tailor individual treatment, with the ability to improve patient outcome further by modifying the underlying tumour biology. © 2007 The Authors.

AB - Objective: The main aim of this article was to review the clinical and biological factors that have been shown to influence the response of the head and neck squamous cell carcinoma (HNSCC) to primary radiotherapy and briefly discuss how some of these factors could be exploited to improve outcome. Design: Medline based search covering 1982-2006 to identify the HNSCC literature where the effect of clinical and biological factors on locoregional control and overall survival were investigated. Results: Clinical factors are routinely used in management decisions. Nevertheless, identically staged tumours receiving the same treatment may have different outcomes. Biological factors such as hypoxia, proliferation and radio-sensitivity play an important role in radiation response. However, these are not currently used in practise because tests that are clinically reliable and feasible are not available. Conclusion: High-quality translational research will allow us to develop biological tests that can be used in routine clinical practise to tailor individual treatment, with the ability to improve patient outcome further by modifying the underlying tumour biology. © 2007 The Authors.

KW - metabolism: Carcinoma, Squamous Cell

KW - radiation effects: Cell Hypoxia

KW - radiation effects: Cell Proliferation

KW - Dose-Response Relationship, Radiation

KW - metabolism: Head and Neck Neoplasms

KW - Humans

KW - metabolism: Tumor Markers, Biological

U2 - 10.1111/j.1749-4486.2007.01544.x

DO - 10.1111/j.1749-4486.2007.01544.x

M3 - Article

VL - 32

SP - 337

EP - 345

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

SN - 1749-4478

IS - 5

ER -