Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patientsCitation formats

  • External authors:
  • Philip J. Lawrence
  • Umme Kolsum
  • Vandana Gupta
  • Gavin Donaldson
  • Richa Singh
  • Bethan Barker
  • Leena George
  • Adam Webb
  • Anthony J. Brookes
  • Christopher Brightling
  • Jadwiga Wedzicha

Standard

Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients. / Lawrence, Philip J.; Kolsum, Umme; Gupta, Vandana; Donaldson, Gavin; Singh, Richa; Barker, Bethan; George, Leena; Webb, Adam; Brookes, Anthony J.; Brightling, Christopher; Wedzicha, Jadwiga; Singh, Dave.

In: BMC Pulmonary Medicine, Vol. 17, No. 1, 42, 20.02.2017.

Research output: Contribution to journalArticlepeer-review

Harvard

Lawrence, PJ, Kolsum, U, Gupta, V, Donaldson, G, Singh, R, Barker, B, George, L, Webb, A, Brookes, AJ, Brightling, C, Wedzicha, J & Singh, D 2017, 'Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients', BMC Pulmonary Medicine, vol. 17, no. 1, 42. https://doi.org/10.1186/s12890-017-0384-8

APA

Lawrence, P. J., Kolsum, U., Gupta, V., Donaldson, G., Singh, R., Barker, B., George, L., Webb, A., Brookes, A. J., Brightling, C., Wedzicha, J., & Singh, D. (2017). Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients. BMC Pulmonary Medicine, 17(1), [42]. https://doi.org/10.1186/s12890-017-0384-8

Vancouver

Lawrence PJ, Kolsum U, Gupta V, Donaldson G, Singh R, Barker B et al. Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients. BMC Pulmonary Medicine. 2017 Feb 20;17(1). 42. https://doi.org/10.1186/s12890-017-0384-8

Author

Lawrence, Philip J. ; Kolsum, Umme ; Gupta, Vandana ; Donaldson, Gavin ; Singh, Richa ; Barker, Bethan ; George, Leena ; Webb, Adam ; Brookes, Anthony J. ; Brightling, Christopher ; Wedzicha, Jadwiga ; Singh, Dave. / Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients. In: BMC Pulmonary Medicine. 2017 ; Vol. 17, No. 1.

Bibtex

@article{26984a691daa480d845fba5055fd11b5,
title = "Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients",
abstract = "Background: The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients in the COPDMAP study were assessed. We aimed to identify the subgroup of patients who progressed to GOLD D (unstable GOLD B patients) and identify characteristics associated with progression. Methods: Three hundred seventy COPD patients were assessed at baseline and 12 months thereafter. Demographics, lung function, health status, 6 min walk tests and levels of systemic inflammation were assessed. Students t tests and Mann Whitney-U tests were used. Results: One hundred seven (28.9%) of patients were categorised as GOLD B at baseline. These GOLD B patients had similar FEV1 to GOLD A patients (66% predicted). More GOLD B patients were current smokers (p = 0.031), had chronic bronchitis (p = 0.0003) and cardiovascular comorbidities (p = 0.019) compared to GOLD A. At 12 months, 25.3% of GOLD B patients progressed to GOLD D. These patients who progressed (unstable patients) had worse health status and symptoms (SGRQ-C Total, 50.0 v 41.1, p = 0.019 and CAT, 21.0 v 14.0, p = 0.006) and lower FEV1 (60% v 69% p = 0.014) at baseline compared to stable patients who remained in GOLD B. Conclusions: Unstable GOLD B patients who progressed to GOLD D had a higher level of symptoms at baseline. A high symptom burden may predict an increased likelihood of disease progression in GOLD B patients.",
keywords = "Classification, Disease Progression, Symptoms",
author = "Lawrence, {Philip J.} and Umme Kolsum and Vandana Gupta and Gavin Donaldson and Richa Singh and Bethan Barker and Leena George and Adam Webb and Brookes, {Anthony J.} and Christopher Brightling and Jadwiga Wedzicha and Dave Singh",
year = "2017",
month = feb,
day = "20",
doi = "10.1186/s12890-017-0384-8",
language = "English",
volume = "17",
journal = "BMC Pulmonary Medicine",
issn = "1471-2466",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

AU - Lawrence, Philip J.

AU - Kolsum, Umme

AU - Gupta, Vandana

AU - Donaldson, Gavin

AU - Singh, Richa

AU - Barker, Bethan

AU - George, Leena

AU - Webb, Adam

AU - Brookes, Anthony J.

AU - Brightling, Christopher

AU - Wedzicha, Jadwiga

AU - Singh, Dave

PY - 2017/2/20

Y1 - 2017/2/20

N2 - Background: The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients in the COPDMAP study were assessed. We aimed to identify the subgroup of patients who progressed to GOLD D (unstable GOLD B patients) and identify characteristics associated with progression. Methods: Three hundred seventy COPD patients were assessed at baseline and 12 months thereafter. Demographics, lung function, health status, 6 min walk tests and levels of systemic inflammation were assessed. Students t tests and Mann Whitney-U tests were used. Results: One hundred seven (28.9%) of patients were categorised as GOLD B at baseline. These GOLD B patients had similar FEV1 to GOLD A patients (66% predicted). More GOLD B patients were current smokers (p = 0.031), had chronic bronchitis (p = 0.0003) and cardiovascular comorbidities (p = 0.019) compared to GOLD A. At 12 months, 25.3% of GOLD B patients progressed to GOLD D. These patients who progressed (unstable patients) had worse health status and symptoms (SGRQ-C Total, 50.0 v 41.1, p = 0.019 and CAT, 21.0 v 14.0, p = 0.006) and lower FEV1 (60% v 69% p = 0.014) at baseline compared to stable patients who remained in GOLD B. Conclusions: Unstable GOLD B patients who progressed to GOLD D had a higher level of symptoms at baseline. A high symptom burden may predict an increased likelihood of disease progression in GOLD B patients.

AB - Background: The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients in the COPDMAP study were assessed. We aimed to identify the subgroup of patients who progressed to GOLD D (unstable GOLD B patients) and identify characteristics associated with progression. Methods: Three hundred seventy COPD patients were assessed at baseline and 12 months thereafter. Demographics, lung function, health status, 6 min walk tests and levels of systemic inflammation were assessed. Students t tests and Mann Whitney-U tests were used. Results: One hundred seven (28.9%) of patients were categorised as GOLD B at baseline. These GOLD B patients had similar FEV1 to GOLD A patients (66% predicted). More GOLD B patients were current smokers (p = 0.031), had chronic bronchitis (p = 0.0003) and cardiovascular comorbidities (p = 0.019) compared to GOLD A. At 12 months, 25.3% of GOLD B patients progressed to GOLD D. These patients who progressed (unstable patients) had worse health status and symptoms (SGRQ-C Total, 50.0 v 41.1, p = 0.019 and CAT, 21.0 v 14.0, p = 0.006) and lower FEV1 (60% v 69% p = 0.014) at baseline compared to stable patients who remained in GOLD B. Conclusions: Unstable GOLD B patients who progressed to GOLD D had a higher level of symptoms at baseline. A high symptom burden may predict an increased likelihood of disease progression in GOLD B patients.

KW - Classification

KW - Disease Progression

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=85013231733&partnerID=8YFLogxK

U2 - 10.1186/s12890-017-0384-8

DO - 10.1186/s12890-017-0384-8

M3 - Article

AN - SCOPUS:85013231733

VL - 17

JO - BMC Pulmonary Medicine

JF - BMC Pulmonary Medicine

SN - 1471-2466

IS - 1

M1 - 42

ER -