Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s DiseaseCitation formats

  • External authors:
  • Li Su
  • Elijah Mak
  • Nasim Sheikh Bahaei
  • Katie Wells
  • Karen Ritchie
  • Adam Waldman
  • Craig Ritchie
  • John O'Brien

Standard

Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease. / Stefaniak, James; Su, Li; Mak, Elijah; Sheikh Bahaei, Nasim; Wells, Katie; Ritchie, Karen; Waldman, Adam; Ritchie, Craig; O'Brien, John.

In: Alzheimer's & Dementia, 2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Stefaniak, J, Su, L, Mak, E, Sheikh Bahaei, N, Wells, K, Ritchie, K, Waldman, A, Ritchie, C & O'Brien, J 2018, 'Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease', Alzheimer's & Dementia. https://doi.org/10.1016/j.jalz.2017.08.017

APA

Stefaniak, J., Su, L., Mak, E., Sheikh Bahaei, N., Wells, K., Ritchie, K., Waldman, A., Ritchie, C., & O'Brien, J. (2018). Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease. Alzheimer's & Dementia. https://doi.org/10.1016/j.jalz.2017.08.017

Vancouver

Author

Stefaniak, James ; Su, Li ; Mak, Elijah ; Sheikh Bahaei, Nasim ; Wells, Katie ; Ritchie, Karen ; Waldman, Adam ; Ritchie, Craig ; O'Brien, John. / Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease. In: Alzheimer's & Dementia. 2018.

Bibtex

@article{ca32cc526dac495499c0aedffe2d00f3,
title = "Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer{\textquoteright}s Disease",
abstract = "INTRODUCTION:Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD.METHODS:We assessed the relationship between radiological markers of CSVD, white matter hyperintensities and microbleeds, and genetic predisposition to LOAD in a cross-sectional analysis of cognitively normal subjects aged 40-59 years recruited from the PREVENT Dementia study.RESULTS:Microbleed prevalence was 14.5%, and mean ± standard deviation white matter hyperintensity percentage of total brain volume was 0.41 ± 0.28%. There was no significant association between APOE ε4 carrier status or history of parental dementia and white matter hyperintensity volume (P = .713, .912 respectively) or microbleeds (P = .082, .562 respectively) on multiple regression.DISCUSSION:Genetic predisposition to LOAD, through APOE genotype or AD family history, is not associated with CSVD in middle age.",
author = "James Stefaniak and Li Su and Elijah Mak and {Sheikh Bahaei}, Nasim and Katie Wells and Karen Ritchie and Adam Waldman and Craig Ritchie and John O'Brien",
year = "2018",
doi = "10.1016/j.jalz.2017.08.017",
language = "English",
journal = "Alzheimer's & Dementia",
issn = "1552-5260",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease

AU - Stefaniak, James

AU - Su, Li

AU - Mak, Elijah

AU - Sheikh Bahaei, Nasim

AU - Wells, Katie

AU - Ritchie, Karen

AU - Waldman, Adam

AU - Ritchie, Craig

AU - O'Brien, John

PY - 2018

Y1 - 2018

N2 - INTRODUCTION:Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD.METHODS:We assessed the relationship between radiological markers of CSVD, white matter hyperintensities and microbleeds, and genetic predisposition to LOAD in a cross-sectional analysis of cognitively normal subjects aged 40-59 years recruited from the PREVENT Dementia study.RESULTS:Microbleed prevalence was 14.5%, and mean ± standard deviation white matter hyperintensity percentage of total brain volume was 0.41 ± 0.28%. There was no significant association between APOE ε4 carrier status or history of parental dementia and white matter hyperintensity volume (P = .713, .912 respectively) or microbleeds (P = .082, .562 respectively) on multiple regression.DISCUSSION:Genetic predisposition to LOAD, through APOE genotype or AD family history, is not associated with CSVD in middle age.

AB - INTRODUCTION:Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD.METHODS:We assessed the relationship between radiological markers of CSVD, white matter hyperintensities and microbleeds, and genetic predisposition to LOAD in a cross-sectional analysis of cognitively normal subjects aged 40-59 years recruited from the PREVENT Dementia study.RESULTS:Microbleed prevalence was 14.5%, and mean ± standard deviation white matter hyperintensity percentage of total brain volume was 0.41 ± 0.28%. There was no significant association between APOE ε4 carrier status or history of parental dementia and white matter hyperintensity volume (P = .713, .912 respectively) or microbleeds (P = .082, .562 respectively) on multiple regression.DISCUSSION:Genetic predisposition to LOAD, through APOE genotype or AD family history, is not associated with CSVD in middle age.

U2 - 10.1016/j.jalz.2017.08.017

DO - 10.1016/j.jalz.2017.08.017

M3 - Article

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

ER -