Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Research output: Contribution to journalArticle

  • External authors:
  • Adam Brook
  • Annie Hoaksey
  • Rekha Gurung
  • Edward E.C. Yoong
  • Rosanna Sneyd
  • Georgia C. Baynes
  • Helen Bischof
  • Sarah Jones
  • Magnus Gram
  • Ingrid Lang
  • Gernot Desoye
  • Henning Schneider
  • Stefan R. Hansson
  • Ian P. Crocker
  • Paul Brownbill

Abstract

© FASEB. Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGRfetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies (P <0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation,which occurs in adults.During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance (P

Bibliographical metadata

Original languageEnglish
Pages (from-to)5436-5446
Number of pages11
JournalFaseb Journal
Volume32
Issue number10
Early online date27 Sep 2018
DOIs
Publication statusPublished - 1 Oct 2018

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