Cation-induced chirality in a bifunctional metal-organic framework 1 for quantitative enantioselective recognition

Research output: Contribution to journalArticle

  • External authors:
  • Zongsu Han
  • Kunyu Wang
  • Yifan Guo
  • Wenjie Chen
  • Jiale Zhang
  • Xinran Zhang
  • Giuliano Siligardi
  • Zhen Zhou
  • Pingchuan Sun
  • Wei Shi
  • Peng Cheng

Abstract

The integration of luminescence and chirality in easy-scalable metal-organic frameworks gives rise to the development of advanced luminescent sensors. To date, the synthesis of chiral metal-organic frameworks is poorly predictable and their chirality primarily originates from components that constitute the frameworks. By contrast, the introduction of chirality into the pores of metal-organic frameworks has not been explored to the best of our knowledge. Here, we demonstrate that chirality can be introduced into an anionic Zn-based metal-organic framework via simple cation-exchange, yielding dual luminescent centers comprised of the ligand and Tb3+ ions, accompanied by a chiral center in the pores. This bifunctional material shows enantioselectivity luminescent sensing for a mixture of stereoisomers, demonstrated for Cinchonine and Cinchonidine epimers and amino alcohol enantiomers, from which the quantitative determination of the stereoisomeric excess has been obtained. This study paves a pathway for the design of multifunctional metal-organic framework systems as a useful method for rapid sensing chiral molecules.

Bibliographical metadata

Original languageEnglish
JournalNature Communications
Publication statusAccepted/In press - 15 Oct 2019