Catechol-hydrazone conjugates for the rapid functionalization of magnetite nanoparticles with cell targeting groups

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Abstract

The condensation of hydrazides with aldehydes has been found to be a simple and rapid method for synthesizing catechol-terminated coating reagents for magnetite nanoparticles. This approach allowed the production of biotin- and polyethylene glycol-functionalized nanoparticles, whose interaction with 3T3 fibroblast cells has been assessed. The cellular location of these nanoparticles was imaged by fluorescence microscopy, which was made possible by co-coating with a porphyrin-catechol conjugate. Images show significant interactions between biotinylated nanoparticles and 3T3 fibroblasts, but those with a polyethylene glycol coating did not interact.

Bibliographical metadata

Original languageEnglish
Article numbermrss14-1688-y08-13
JournalMaterials Research Society Symposium Proceedings
Volume1688
DOIs
StatePublished - 2014