Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

Research output: Contribution to journalArticle

  • External authors:
  • Beatrice Bechi
  • Susanne Herter
  • Shane McKenna
  • Christopher Riley
  • Silke Leimkühler
  • Andrew J. Carnell


A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H2O2) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.

Bibliographical metadata

Original languageEnglish
Article numberC4GC01321B
Pages (from-to)4524-4529
Number of pages5
JournalGreen Chemistry
Publication statusPublished - 18 Aug 2014