Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B: Mimicry of Monoamine Oxidase B

Research output: Contribution to journalArticle

  • External authors:
  • Alexander T Murray
  • Myles J H Dowley
  • Fabienne Pradaux-Caggiano
  • Amgalanbaatar Baldansuren
  • Floriana Tuna
  • Christopher H Hendon
  • Aron Walsh
  • Guy C Lloyd-Jones
  • Matthew P John
  • David R Carbery

Abstract

The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase B activity.

Bibliographical metadata

Original languageEnglish
Pages (from-to)8997-9000
Number of pages4
JournalAngewandte Chemie (International ed. in English)
Volume54
Issue number31
DOIs
StatePublished - 27 Jul 2015