Cardiac Transverse Tubules in Physiology and Heart Failure

Research output: Contribution to journalReview articlepeer-review


In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowing efficient triggering of Ca release and initiation of contraction. Once thought to serve as rather static enablers of excitation-contraction coupling, recent work has provided a newfound appreciation of the plasticity of the t-tubule network's structure and function. Indeed, t-tubules are now understood to support dynamic regulation of the heartbeat across a range of timescales, during all stages of life, in both health and disease. This review article aims to summarize these concepts, with consideration given to emerging t-tubule regulators and their targeting in future therapies.

Bibliographical metadata

Original languageEnglish
Pages (from-to)229-255
Number of pages27
JournalAnnual Review of Physiology
Issue number1
Early online date15 Nov 2021
Publication statusPublished - 10 Feb 2022