Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heartCitation formats

  • External authors:
  • Mihaela Ghita
  • Eleanor K Gill
  • Gerard M Walls
  • Kevin S Edgar
  • Stephen J McMahon
  • Carmen Bergom
  • David J Grieve
  • Chris J Watson
  • Karl T Butterworth

Standard

Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. / Ghita, Mihaela; Gill, Eleanor K; Walls, Gerard M; Edgar, Kevin S; McMahon, Stephen J; Osorio, Eliana Vasquez; Bergom, Carmen; Grieve, David J; Watson, Chris J; McWilliam, Alan; Aznar, Marianne; van Herk, Marcel; Williams, Kaye J; Butterworth, Karl T.

In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 11.07.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Ghita, M, Gill, EK, Walls, GM, Edgar, KS, McMahon, SJ, Osorio, EV, Bergom, C, Grieve, DJ, Watson, CJ, McWilliam, A, Aznar, M, van Herk, M, Williams, KJ & Butterworth, KT 2020, 'Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. https://doi.org/10.1016/j.radonc.2020.07.016

APA

Ghita, M., Gill, E. K., Walls, G. M., Edgar, K. S., McMahon, S. J., Osorio, E. V., Bergom, C., Grieve, D. J., Watson, C. J., McWilliam, A., Aznar, M., van Herk, M., Williams, K. J., & Butterworth, K. T. (2020). Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. https://doi.org/10.1016/j.radonc.2020.07.016

Vancouver

Ghita M, Gill EK, Walls GM, Edgar KS, McMahon SJ, Osorio EV et al. Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2020 Jul 11. https://doi.org/10.1016/j.radonc.2020.07.016

Author

Ghita, Mihaela ; Gill, Eleanor K ; Walls, Gerard M ; Edgar, Kevin S ; McMahon, Stephen J ; Osorio, Eliana Vasquez ; Bergom, Carmen ; Grieve, David J ; Watson, Chris J ; McWilliam, Alan ; Aznar, Marianne ; van Herk, Marcel ; Williams, Kaye J ; Butterworth, Karl T. / Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2020.

Bibtex

@article{8a38af15b11f4acdbd3af49e1ec8b518,
title = "Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart",
abstract = "Background and purpose: Radiation-induced cardiac toxicity (RICT) remains one of the most critical dose limiting constraints in radiotherapy. Recent studies have shown higher doses to the base of the heart are associated with worse overall survival in lung cancer patients receiving radiotherapy. This work aimed to investigate the impact of sub-volume heart irradiation in a mouse model using small animal image-guided radiotherapy. Materials and methods: C57BL/6 mice were irradiated with a single fraction of 16 Gy to the base, middle or apex of the heart using a small animal radiotherapy research platform. Cone beam CT and echocardiography were performed at baseline and at 10 week intervals until 50 weeks post-treatment. Structural and functional parameters were correlated with mean heart dose (MHD) and volume of heart receiving 5 Gy (V5). Results: All irradiated mice showed a time dependent increase in left ventricle wall thickness in diastole of ~0.2 mm detected at 10 weeks post-treatment, with the most significant and persistent changes occurring in the heart base-irradiated animals. Similarly, statistically different functional effects (p < 0.01) were observed in base-irradiated animals which showed the most significant decreases compared to controls. The observed functional changes did not correlate with MHD and V5 (R 2 < 0.1), indicating that whole heart dosimetry parameters do not predict physiological changes resulting from cardiac sub-volume irradiation. Conclusions: This is the first report demonstrating the structural and functional consequences of sub-volume targeting in the mouse heart and reverse translates clinical observations indicating the heart base as a critical radiosensitive region. ",
keywords = "Cardiac toxicity, Heart dose, Mouse model, Preclinical radiotherapy, Small animal radiotherapy",
author = "Mihaela Ghita and Gill, {Eleanor K} and Walls, {Gerard M} and Edgar, {Kevin S} and McMahon, {Stephen J} and Osorio, {Eliana Vasquez} and Carmen Bergom and Grieve, {David J} and Watson, {Chris J} and Alan McWilliam and Marianne Aznar and {van Herk}, Marcel and Williams, {Kaye J} and Butterworth, {Karl T}",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = jul,
day = "11",
doi = "10.1016/j.radonc.2020.07.016",
language = "English",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

AU - Ghita, Mihaela

AU - Gill, Eleanor K

AU - Walls, Gerard M

AU - Edgar, Kevin S

AU - McMahon, Stephen J

AU - Osorio, Eliana Vasquez

AU - Bergom, Carmen

AU - Grieve, David J

AU - Watson, Chris J

AU - McWilliam, Alan

AU - Aznar, Marianne

AU - van Herk, Marcel

AU - Williams, Kaye J

AU - Butterworth, Karl T

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/7/11

Y1 - 2020/7/11

N2 - Background and purpose: Radiation-induced cardiac toxicity (RICT) remains one of the most critical dose limiting constraints in radiotherapy. Recent studies have shown higher doses to the base of the heart are associated with worse overall survival in lung cancer patients receiving radiotherapy. This work aimed to investigate the impact of sub-volume heart irradiation in a mouse model using small animal image-guided radiotherapy. Materials and methods: C57BL/6 mice were irradiated with a single fraction of 16 Gy to the base, middle or apex of the heart using a small animal radiotherapy research platform. Cone beam CT and echocardiography were performed at baseline and at 10 week intervals until 50 weeks post-treatment. Structural and functional parameters were correlated with mean heart dose (MHD) and volume of heart receiving 5 Gy (V5). Results: All irradiated mice showed a time dependent increase in left ventricle wall thickness in diastole of ~0.2 mm detected at 10 weeks post-treatment, with the most significant and persistent changes occurring in the heart base-irradiated animals. Similarly, statistically different functional effects (p < 0.01) were observed in base-irradiated animals which showed the most significant decreases compared to controls. The observed functional changes did not correlate with MHD and V5 (R 2 < 0.1), indicating that whole heart dosimetry parameters do not predict physiological changes resulting from cardiac sub-volume irradiation. Conclusions: This is the first report demonstrating the structural and functional consequences of sub-volume targeting in the mouse heart and reverse translates clinical observations indicating the heart base as a critical radiosensitive region.

AB - Background and purpose: Radiation-induced cardiac toxicity (RICT) remains one of the most critical dose limiting constraints in radiotherapy. Recent studies have shown higher doses to the base of the heart are associated with worse overall survival in lung cancer patients receiving radiotherapy. This work aimed to investigate the impact of sub-volume heart irradiation in a mouse model using small animal image-guided radiotherapy. Materials and methods: C57BL/6 mice were irradiated with a single fraction of 16 Gy to the base, middle or apex of the heart using a small animal radiotherapy research platform. Cone beam CT and echocardiography were performed at baseline and at 10 week intervals until 50 weeks post-treatment. Structural and functional parameters were correlated with mean heart dose (MHD) and volume of heart receiving 5 Gy (V5). Results: All irradiated mice showed a time dependent increase in left ventricle wall thickness in diastole of ~0.2 mm detected at 10 weeks post-treatment, with the most significant and persistent changes occurring in the heart base-irradiated animals. Similarly, statistically different functional effects (p < 0.01) were observed in base-irradiated animals which showed the most significant decreases compared to controls. The observed functional changes did not correlate with MHD and V5 (R 2 < 0.1), indicating that whole heart dosimetry parameters do not predict physiological changes resulting from cardiac sub-volume irradiation. Conclusions: This is the first report demonstrating the structural and functional consequences of sub-volume targeting in the mouse heart and reverse translates clinical observations indicating the heart base as a critical radiosensitive region.

KW - Cardiac toxicity

KW - Heart dose

KW - Mouse model

KW - Preclinical radiotherapy

KW - Small animal radiotherapy

U2 - 10.1016/j.radonc.2020.07.016

DO - 10.1016/j.radonc.2020.07.016

M3 - Article

C2 - 32663535

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -