Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Edward JM Monk
  • Alice Montalti
  • Richard Templeton
  • Alan Ashworth
  • Miguel Garcia
  • Julian Barker
  • Stephanie Thomas

Abstract

This single-centre retrospective study reports the dynamics of Candida bloodstream infection (CBSI) incidence in 145 patients receiving venovenous ECMO for respiratory support, between January 2014 and December 2018. Incidence rate and odds ratio (OR) of CBSI were calculated, stratified by week of ECMO exposure. Weekly incidence increased throughout the ECMO run, with a rising trend in OR (P = 0.005), and a window of continued risk after decannulation was observed. Of the 13 patients that developed CBSI, five (38%) received empirical micafungin treatment before positive culture due to clinical suspicion. Prospective studies, aiming to improve ECMO diagnostic stewardship practices and discourage antifungal prophylaxis or empiric management where unnecessary, are needed.

Bibliographical metadata

Original languageEnglish
JournalJournal of Hospital Infection
Publication statusAccepted/In press - 20 Sep 2021

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