Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in PolandCitation formats

  • Authors:
  • Frank de Vocht
  • Wojciech Sobala
  • Urszula Wilczynska
  • Hans Kromhout
  • Neonila Szeszenia-Dabrowska
  • And 1 others
  • External authors:
  • Beata Peplonska

Standard

Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland. / de Vocht, Frank; Sobala, Wojciech; Wilczynska, Urszula; Kromhout, Hans; Szeszenia-Dabrowska, Neonila; Peplonska, Beata.

In: Cancer Epidemiology, Vol. 33, No. 2, 08.2009, p. 94-102.

Research output: Contribution to journalArticle

Harvard

de Vocht, F, Sobala, W, Wilczynska, U, Kromhout, H, Szeszenia-Dabrowska, N & Peplonska, B 2009, 'Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland' Cancer Epidemiology, vol. 33, no. 2, pp. 94-102. https://doi.org/10.1016/j.canep.2009.06.013

APA

de Vocht, F., Sobala, W., Wilczynska, U., Kromhout, H., Szeszenia-Dabrowska, N., & Peplonska, B. (2009). Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland. Cancer Epidemiology, 33(2), 94-102. https://doi.org/10.1016/j.canep.2009.06.013

Vancouver

de Vocht F, Sobala W, Wilczynska U, Kromhout H, Szeszenia-Dabrowska N, Peplonska B. Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland. Cancer Epidemiology. 2009 Aug;33(2):94-102. https://doi.org/10.1016/j.canep.2009.06.013

Author

de Vocht, Frank ; Sobala, Wojciech ; Wilczynska, Urszula ; Kromhout, Hans ; Szeszenia-Dabrowska, Neonila ; Peplonska, Beata. / Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland. In: Cancer Epidemiology. 2009 ; Vol. 33, No. 2. pp. 94-102.

Bibtex

@article{207ec8aafbff4a32ab30297918782a7f,
title = "Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland",
abstract = "Aim: Most data on carcinogenic risk in the rubber industry are based on data from Western countries. This study assessed cancer risks in a retrospective cohort in a Polish tire manufacturing plant, relying on quantified exposure to inhalable aerosols and aromatic amines instead of job titles or external comparisons. Methods: Cumulative exposure for all exposures was assigned to cohort members based on estimates from a company-specific JEM. Cancer risks associated with cumulative exposure adjusted for co-exposures, gender and year of birth were calculated. Results: Exposure levels were higher for women than for men. Aromatic amine exposure was significantly associated with increased urinary bladder cancer risk (RR = 7.32-8.27), depending on exposure level, and prostate cancer at low levels only (RR = 5.86). In women, increased risks were found for all cancers (RR = 2.50) and of the digestive organs and peritoneum (RR = 4.54) at low level only, while an exposure-response association with breast cancer risk was found. Inhalable aerosol exposure was associated with cancers of the liver and intrahepatic bile ducts in a dose-dependent manner, while dose-dependent reduced risks were found for respiratory cancers (most notably the larynx) and cancer of the colon. Conclusions: Increased risks for specific cancer sites in this rubber plant were similar to Western Europe and the US. However, several cancer risks were gender-specific which could relate to higher exposure levels in women or to differences in exposures to chemicals not assessed in this study. Crown Copyright {\circledC} 2009.",
keywords = "Aromatic amines, Cancer risk, Inhalable aerosols, Occupational cohort, Rubber manufacturing",
author = "{de Vocht}, Frank and Wojciech Sobala and Urszula Wilczynska and Hans Kromhout and Neonila Szeszenia-Dabrowska and Beata Peplonska",
note = "This work was sponsored by the European Union 6th Framework Programme's Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS) project (FOOD-CT-2005-513943). Exposure data came from the EXASRUB database that was elaborated in a Concerted Action sponsored by the European Union (QLK4-CT-2001-00160, QLRT-2001-02786) and the JEM was constructed within the European Union Transfer of Knowledge in Molecular and Epidemiology of Occupational and Environmental Cancer (EPITOK) (MTKD-CT-2004-509829).",
year = "2009",
month = "8",
doi = "10.1016/j.canep.2009.06.013",
language = "English",
volume = "33",
pages = "94--102",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Cancer mortality and occupational exposure to aromatic amines and inhalable aerosols in rubber tire manufacturing in Poland

AU - de Vocht, Frank

AU - Sobala, Wojciech

AU - Wilczynska, Urszula

AU - Kromhout, Hans

AU - Szeszenia-Dabrowska, Neonila

AU - Peplonska, Beata

N1 - This work was sponsored by the European Union 6th Framework Programme's Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS) project (FOOD-CT-2005-513943). Exposure data came from the EXASRUB database that was elaborated in a Concerted Action sponsored by the European Union (QLK4-CT-2001-00160, QLRT-2001-02786) and the JEM was constructed within the European Union Transfer of Knowledge in Molecular and Epidemiology of Occupational and Environmental Cancer (EPITOK) (MTKD-CT-2004-509829).

PY - 2009/8

Y1 - 2009/8

N2 - Aim: Most data on carcinogenic risk in the rubber industry are based on data from Western countries. This study assessed cancer risks in a retrospective cohort in a Polish tire manufacturing plant, relying on quantified exposure to inhalable aerosols and aromatic amines instead of job titles or external comparisons. Methods: Cumulative exposure for all exposures was assigned to cohort members based on estimates from a company-specific JEM. Cancer risks associated with cumulative exposure adjusted for co-exposures, gender and year of birth were calculated. Results: Exposure levels were higher for women than for men. Aromatic amine exposure was significantly associated with increased urinary bladder cancer risk (RR = 7.32-8.27), depending on exposure level, and prostate cancer at low levels only (RR = 5.86). In women, increased risks were found for all cancers (RR = 2.50) and of the digestive organs and peritoneum (RR = 4.54) at low level only, while an exposure-response association with breast cancer risk was found. Inhalable aerosol exposure was associated with cancers of the liver and intrahepatic bile ducts in a dose-dependent manner, while dose-dependent reduced risks were found for respiratory cancers (most notably the larynx) and cancer of the colon. Conclusions: Increased risks for specific cancer sites in this rubber plant were similar to Western Europe and the US. However, several cancer risks were gender-specific which could relate to higher exposure levels in women or to differences in exposures to chemicals not assessed in this study. Crown Copyright © 2009.

AB - Aim: Most data on carcinogenic risk in the rubber industry are based on data from Western countries. This study assessed cancer risks in a retrospective cohort in a Polish tire manufacturing plant, relying on quantified exposure to inhalable aerosols and aromatic amines instead of job titles or external comparisons. Methods: Cumulative exposure for all exposures was assigned to cohort members based on estimates from a company-specific JEM. Cancer risks associated with cumulative exposure adjusted for co-exposures, gender and year of birth were calculated. Results: Exposure levels were higher for women than for men. Aromatic amine exposure was significantly associated with increased urinary bladder cancer risk (RR = 7.32-8.27), depending on exposure level, and prostate cancer at low levels only (RR = 5.86). In women, increased risks were found for all cancers (RR = 2.50) and of the digestive organs and peritoneum (RR = 4.54) at low level only, while an exposure-response association with breast cancer risk was found. Inhalable aerosol exposure was associated with cancers of the liver and intrahepatic bile ducts in a dose-dependent manner, while dose-dependent reduced risks were found for respiratory cancers (most notably the larynx) and cancer of the colon. Conclusions: Increased risks for specific cancer sites in this rubber plant were similar to Western Europe and the US. However, several cancer risks were gender-specific which could relate to higher exposure levels in women or to differences in exposures to chemicals not assessed in this study. Crown Copyright © 2009.

KW - Aromatic amines

KW - Cancer risk

KW - Inhalable aerosols

KW - Occupational cohort

KW - Rubber manufacturing

U2 - 10.1016/j.canep.2009.06.013

DO - 10.1016/j.canep.2009.06.013

M3 - Article

VL - 33

SP - 94

EP - 102

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 2

ER -