Bright daytime light enhances circadian amplitude in a diurnal mammalCitation formats

  • External authors:
  • Franck Martial
  • Court Harding
  • Mino D C Belle

Standard

Bright daytime light enhances circadian amplitude in a diurnal mammal. / Bano-Otalora, Beatriz; Martial, Franck; Harding, Court; Bechtold, David A; Allen, Annette E; Brown, Timothy M; Belle, Mino D C; Lucas, Robert J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 22, e2100094118, 01.06.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Bano-Otalora, B, Martial, F, Harding, C, Bechtold, DA, Allen, AE, Brown, TM, Belle, MDC & Lucas, RJ 2021, 'Bright daytime light enhances circadian amplitude in a diurnal mammal', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 22, e2100094118. https://doi.org/10.1073/pnas.2100094118

APA

Bano-Otalora, B., Martial, F., Harding, C., Bechtold, D. A., Allen, A. E., Brown, T. M., Belle, M. D. C., & Lucas, R. J. (2021). Bright daytime light enhances circadian amplitude in a diurnal mammal. Proceedings of the National Academy of Sciences of the United States of America, 118(22), [e2100094118]. https://doi.org/10.1073/pnas.2100094118

Vancouver

Bano-Otalora B, Martial F, Harding C, Bechtold DA, Allen AE, Brown TM et al. Bright daytime light enhances circadian amplitude in a diurnal mammal. Proceedings of the National Academy of Sciences of the United States of America. 2021 Jun 1;118(22). e2100094118. https://doi.org/10.1073/pnas.2100094118

Author

Bano-Otalora, Beatriz ; Martial, Franck ; Harding, Court ; Bechtold, David A ; Allen, Annette E ; Brown, Timothy M ; Belle, Mino D C ; Lucas, Robert J. / Bright daytime light enhances circadian amplitude in a diurnal mammal. In: Proceedings of the National Academy of Sciences of the United States of America. 2021 ; Vol. 118, No. 22.

Bibtex

@article{f4041e1b4a7243af8f54a7d617e6380d,
title = "Bright daytime light enhances circadian amplitude in a diurnal mammal",
abstract = "Mammalian circadian rhythms are orchestrated by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), which receives information about the 24 h light-dark cycle from the retina. The accepted function of this light signal is to reset circadian phase in order to ensure appropriate synchronization with the celestial day. Here, we ask whether light also impacts another key property of the circadian oscillation, its amplitude. To this end, we measured circadian rhythms in behavioral activity, body temperature, and SCN electrophysiological activity in the diurnal murid rodent Rhabdomys pumilio following stable entrainment to 12:12 light-dark cycles at four different daytime intensities (ranging from 18 to 1,900 lx melanopic equivalent daylight illuminance). R. pumilio showed strongly diurnal activity and body temperature rhythms in all conditions, but measures of rhythm robustness were positively correlated with daytime irradiance under both entrainment and subsequent free run. Whole-cell and extracellular recordings of electrophysiological activity in ex vivo SCN revealed substantial differences in electrophysiological activity between dim and bright light conditions. At lower daytime irradiance, daytime peaks in SCN spontaneous firing rate and membrane depolarization were substantially depressed, leading to an overall marked reduction in the amplitude of circadian rhythms in spontaneous activity. Our data reveal a previously unappreciated impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms and highlight the potential importance of daytime light exposure for circadian health.",
keywords = "Circadian, Light, Retina, Suprachiasmatic nucleus",
author = "Beatriz Bano-Otalora and Franck Martial and Court Harding and Bechtold, {David A} and Allen, {Annette E} and Brown, {Timothy M} and Belle, {Mino D C} and Lucas, {Robert J}",
note = "Funding Information: Competing interest statement: T.M.B. and R.J.L. have received investigator-initiated grant funding from Signify (formerly Philips Lighting). R.J.L. has received honoraria from Samsung Electronics. Funding Information: We thank the members of the University of Manchester Biological Services Facility and Jonathan Wynne for their excellent assistance in colony maintenance and husbandry. We also thank Professor Simon Luckman for allowing us access to his electrophysiology equipment and Dr. Josh Mouland for his assistance with light measurements. This work was funded by a Biotechnology and Biological Sciences Research Council (BBSRC) Industrial Partnership Award with Signify (BB/P009182/1) to R.J.L. and T.M.B., by grants from the BBSRC to T.M.B. (B/N014901/1) and to M.D.C.B. (BB/S01764X/1), and the Wellcome Trust (210684/Z/18/Z) to R.J.L. Publisher Copyright: {\textcopyright} 2021 National Academy of Sciences. All rights reserved.",
year = "2021",
month = jun,
day = "1",
doi = "10.1073/pnas.2100094118",
language = "English",
volume = "118",
journal = "Proceedings of the National Academy of Sciences",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "22",

}

RIS

TY - JOUR

T1 - Bright daytime light enhances circadian amplitude in a diurnal mammal

AU - Bano-Otalora, Beatriz

AU - Martial, Franck

AU - Harding, Court

AU - Bechtold, David A

AU - Allen, Annette E

AU - Brown, Timothy M

AU - Belle, Mino D C

AU - Lucas, Robert J

N1 - Funding Information: Competing interest statement: T.M.B. and R.J.L. have received investigator-initiated grant funding from Signify (formerly Philips Lighting). R.J.L. has received honoraria from Samsung Electronics. Funding Information: We thank the members of the University of Manchester Biological Services Facility and Jonathan Wynne for their excellent assistance in colony maintenance and husbandry. We also thank Professor Simon Luckman for allowing us access to his electrophysiology equipment and Dr. Josh Mouland for his assistance with light measurements. This work was funded by a Biotechnology and Biological Sciences Research Council (BBSRC) Industrial Partnership Award with Signify (BB/P009182/1) to R.J.L. and T.M.B., by grants from the BBSRC to T.M.B. (B/N014901/1) and to M.D.C.B. (BB/S01764X/1), and the Wellcome Trust (210684/Z/18/Z) to R.J.L. Publisher Copyright: © 2021 National Academy of Sciences. All rights reserved.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Mammalian circadian rhythms are orchestrated by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), which receives information about the 24 h light-dark cycle from the retina. The accepted function of this light signal is to reset circadian phase in order to ensure appropriate synchronization with the celestial day. Here, we ask whether light also impacts another key property of the circadian oscillation, its amplitude. To this end, we measured circadian rhythms in behavioral activity, body temperature, and SCN electrophysiological activity in the diurnal murid rodent Rhabdomys pumilio following stable entrainment to 12:12 light-dark cycles at four different daytime intensities (ranging from 18 to 1,900 lx melanopic equivalent daylight illuminance). R. pumilio showed strongly diurnal activity and body temperature rhythms in all conditions, but measures of rhythm robustness were positively correlated with daytime irradiance under both entrainment and subsequent free run. Whole-cell and extracellular recordings of electrophysiological activity in ex vivo SCN revealed substantial differences in electrophysiological activity between dim and bright light conditions. At lower daytime irradiance, daytime peaks in SCN spontaneous firing rate and membrane depolarization were substantially depressed, leading to an overall marked reduction in the amplitude of circadian rhythms in spontaneous activity. Our data reveal a previously unappreciated impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms and highlight the potential importance of daytime light exposure for circadian health.

AB - Mammalian circadian rhythms are orchestrated by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), which receives information about the 24 h light-dark cycle from the retina. The accepted function of this light signal is to reset circadian phase in order to ensure appropriate synchronization with the celestial day. Here, we ask whether light also impacts another key property of the circadian oscillation, its amplitude. To this end, we measured circadian rhythms in behavioral activity, body temperature, and SCN electrophysiological activity in the diurnal murid rodent Rhabdomys pumilio following stable entrainment to 12:12 light-dark cycles at four different daytime intensities (ranging from 18 to 1,900 lx melanopic equivalent daylight illuminance). R. pumilio showed strongly diurnal activity and body temperature rhythms in all conditions, but measures of rhythm robustness were positively correlated with daytime irradiance under both entrainment and subsequent free run. Whole-cell and extracellular recordings of electrophysiological activity in ex vivo SCN revealed substantial differences in electrophysiological activity between dim and bright light conditions. At lower daytime irradiance, daytime peaks in SCN spontaneous firing rate and membrane depolarization were substantially depressed, leading to an overall marked reduction in the amplitude of circadian rhythms in spontaneous activity. Our data reveal a previously unappreciated impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms and highlight the potential importance of daytime light exposure for circadian health.

KW - Circadian

KW - Light

KW - Retina

KW - Suprachiasmatic nucleus

U2 - 10.1073/pnas.2100094118

DO - 10.1073/pnas.2100094118

M3 - Article

C2 - 34031246

VL - 118

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 0027-8424

IS - 22

M1 - e2100094118

ER -