Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative StudyCitation formats

  • External authors:
  • Minas Leventis
  • Peter Fairbairn
  • Antonios Galanos
  • Orestis Vasiliadis
  • Danai Papavasileiou
  • Robert Horowitz

Standard

Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study. / Leventis, Minas; Fairbairn, Peter; Mangham, Chas; Galanos, Antonios; Vasiliadis, Orestis; Papavasileiou, Danai; Horowitz, Robert.

In: Materials, Vol. 11, No. 10, 2004, 17.10.2018, p. 2004.

Research output: Contribution to journalArticlepeer-review

Harvard

Leventis, M, Fairbairn, P, Mangham, C, Galanos, A, Vasiliadis, O, Papavasileiou, D & Horowitz, R 2018, 'Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study', Materials, vol. 11, no. 10, 2004, pp. 2004. https://doi.org/10.3390/ma11102004

APA

Leventis, M., Fairbairn, P., Mangham, C., Galanos, A., Vasiliadis, O., Papavasileiou, D., & Horowitz, R. (2018). Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study. Materials, 11(10), 2004. [2004]. https://doi.org/10.3390/ma11102004

Vancouver

Leventis M, Fairbairn P, Mangham C, Galanos A, Vasiliadis O, Papavasileiou D et al. Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study. Materials. 2018 Oct 17;11(10):2004. 2004. https://doi.org/10.3390/ma11102004

Author

Leventis, Minas ; Fairbairn, Peter ; Mangham, Chas ; Galanos, Antonios ; Vasiliadis, Orestis ; Papavasileiou, Danai ; Horowitz, Robert. / Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study. In: Materials. 2018 ; Vol. 11, No. 10. pp. 2004.

Bibtex

@article{9d78c762667749d48a69cd098b60f944,
title = "Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study",
abstract = "Bioactive alloplastic materials, like beta-tricalcium phosphate (β-TCP) and calcium sulfate (CS), have been extensively researched and are currently used in orthopedic and dental bone regenerative procedures. The purpose of this study was to compare the performance of EthOss versus a bovine xenograft and spontaneous healing. The grafting materials were implanted in standardized 8 mm circular bicortical bone defects in rabbit calvariae. A third similar defect in each animal was left empty for natural healing. Six male rabbits were used. After eight weeks of healing, the animals were euthanized and the bone tissue was analyzed using histology and micro-computed tomography (micro-CT). Defects treated with β-TCP/CS showed the greatest bone regeneration and graft resorption, although differences between groups were not statistically significant. At sites that healed spontaneously, the trabecular number was lower (p < 0.05) and trabecular separation was higher (p < 0.05), compared to sites treated with β-TCP/CS or xenograft. Trabecular thickness was higher at sites treated with the bovine xenograft (p < 0.05) compared to sites filled with β-TCP/CS or sites that healed spontaneously. In conclusion, the novel β -TCP/CS grafting material performed well as a bioactive and biomimetic alloplastic bone substitute when used in cranial defects in this animal model.",
keywords = "Animal study, Bone regeneration, Bone substitutes, Calcium sulfate, β-tricalcium phosphate",
author = "Minas Leventis and Peter Fairbairn and Chas Mangham and Antonios Galanos and Orestis Vasiliadis and Danai Papavasileiou and Robert Horowitz",
year = "2018",
month = oct,
day = "17",
doi = "10.3390/ma11102004",
language = "English",
volume = "11",
pages = "2004",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI",
number = "10",

}

RIS

TY - JOUR

T1 - Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study

AU - Leventis, Minas

AU - Fairbairn, Peter

AU - Mangham, Chas

AU - Galanos, Antonios

AU - Vasiliadis, Orestis

AU - Papavasileiou, Danai

AU - Horowitz, Robert

PY - 2018/10/17

Y1 - 2018/10/17

N2 - Bioactive alloplastic materials, like beta-tricalcium phosphate (β-TCP) and calcium sulfate (CS), have been extensively researched and are currently used in orthopedic and dental bone regenerative procedures. The purpose of this study was to compare the performance of EthOss versus a bovine xenograft and spontaneous healing. The grafting materials were implanted in standardized 8 mm circular bicortical bone defects in rabbit calvariae. A third similar defect in each animal was left empty for natural healing. Six male rabbits were used. After eight weeks of healing, the animals were euthanized and the bone tissue was analyzed using histology and micro-computed tomography (micro-CT). Defects treated with β-TCP/CS showed the greatest bone regeneration and graft resorption, although differences between groups were not statistically significant. At sites that healed spontaneously, the trabecular number was lower (p < 0.05) and trabecular separation was higher (p < 0.05), compared to sites treated with β-TCP/CS or xenograft. Trabecular thickness was higher at sites treated with the bovine xenograft (p < 0.05) compared to sites filled with β-TCP/CS or sites that healed spontaneously. In conclusion, the novel β -TCP/CS grafting material performed well as a bioactive and biomimetic alloplastic bone substitute when used in cranial defects in this animal model.

AB - Bioactive alloplastic materials, like beta-tricalcium phosphate (β-TCP) and calcium sulfate (CS), have been extensively researched and are currently used in orthopedic and dental bone regenerative procedures. The purpose of this study was to compare the performance of EthOss versus a bovine xenograft and spontaneous healing. The grafting materials were implanted in standardized 8 mm circular bicortical bone defects in rabbit calvariae. A third similar defect in each animal was left empty for natural healing. Six male rabbits were used. After eight weeks of healing, the animals were euthanized and the bone tissue was analyzed using histology and micro-computed tomography (micro-CT). Defects treated with β-TCP/CS showed the greatest bone regeneration and graft resorption, although differences between groups were not statistically significant. At sites that healed spontaneously, the trabecular number was lower (p < 0.05) and trabecular separation was higher (p < 0.05), compared to sites treated with β-TCP/CS or xenograft. Trabecular thickness was higher at sites treated with the bovine xenograft (p < 0.05) compared to sites filled with β-TCP/CS or sites that healed spontaneously. In conclusion, the novel β -TCP/CS grafting material performed well as a bioactive and biomimetic alloplastic bone substitute when used in cranial defects in this animal model.

KW - Animal study

KW - Bone regeneration

KW - Bone substitutes

KW - Calcium sulfate

KW - β-tricalcium phosphate

UR - http://www.scopus.com/inward/record.url?scp=85054991841&partnerID=8YFLogxK

U2 - 10.3390/ma11102004

DO - 10.3390/ma11102004

M3 - Article

C2 - 30336544

VL - 11

SP - 2004

JO - Materials

JF - Materials

SN - 1996-1944

IS - 10

M1 - 2004

ER -