Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Research output: Contribution to journalArticle

Abstract

Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.

Bibliographical metadata

Original languageEnglish
Pages (from-to)11316-11319
Number of pages4
JournalChemical Communications
Volume54
Issue number80
Early online date17 Sep 2018
DOIs
Publication statusPublished - 2018