Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide SurfacesCitation formats

  • External authors:
  • Nathalie Willems
  • Ainhoa Urtizberea
  • Andrea F. Verre
  • Mickael Lelimousin
  • Michael Hirtz
  • Mark S P Sansom

Standard

Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide Surfaces : A Molecular Dynamics Simulation Study. / Willems, Nathalie; Urtizberea, Ainhoa; Verre, Andrea F.; Iliut, Maria; Lelimousin, Mickael; Hirtz, Michael; Vijayaraghavan, Aravind; Sansom, Mark S P.

In: ACS Nano, Vol. 11, No. 2, 06.02.2017, p. 1613-1625.

Research output: Contribution to journalArticle

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APA

Willems, N., Urtizberea, A., Verre, A. F., Iliut, M., Lelimousin, M., Hirtz, M., ... Sansom, M. S. P. (2017). Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide Surfaces: A Molecular Dynamics Simulation Study. ACS Nano, 11(2), 1613-1625. https://doi.org/10.1021/acsnano.6b07352

Vancouver

Author

Willems, Nathalie ; Urtizberea, Ainhoa ; Verre, Andrea F. ; Iliut, Maria ; Lelimousin, Mickael ; Hirtz, Michael ; Vijayaraghavan, Aravind ; Sansom, Mark S P. / Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide Surfaces : A Molecular Dynamics Simulation Study. In: ACS Nano. 2017 ; Vol. 11, No. 2. pp. 1613-1625.

Bibtex

@article{c0752fdf236a43c0b90fabbdd303f3cc,
title = "Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide Surfaces: A Molecular Dynamics Simulation Study",
abstract = "Supported phospholipid membrane patches stabilized on graphene surfaces have shown potential in sensor device functionalization, including biosensors and biocatalysis. Lipid dip-pen nanolithography (L-DPN) is a method useful in generating supported membrane structures that maintain lipid functionality, such as exhibiting specific interactions with protein molecules. Here, we have integrated L-DPN, atomic force microscopy, and coarse-grained molecular dynamics simulation methods to characterize the molecular properties of supported lipid membranes (SLMs) on graphene and graphene oxide supports. We observed substantial differences in the topologies of the stabilized lipid structures depending on the nature of the surface (polar graphene oxide vs nonpolar graphene). Furthermore, the addition of water to SLM systems resulted in large-scale reorganization of the lipid structures, with measurable effects on lipid lateral mobility within the supported membranes. We also observed reduced lipid ordering within the supported structures relative to free-standing lipid bilayers, attributed to the strong hydrophobic interactions between the lipids and support. Together, our results provide insight into the molecular effects of graphene and graphene oxide surfaces on lipid bilayer membranes. This will be important in the design of these surfaces for applications such as biosensor devices.",
keywords = "dip-pen nanolithography, molecular dynamics, phospholipid bilayer, polymer pen lithography, supported lipid membranes",
author = "Nathalie Willems and Ainhoa Urtizberea and Verre, {Andrea F.} and Maria Iliut and Mickael Lelimousin and Michael Hirtz and Aravind Vijayaraghavan and Sansom, {Mark S P}",
year = "2017",
month = "2",
day = "6",
doi = "10.1021/acsnano.6b07352",
language = "English",
volume = "11",
pages = "1613--1625",
journal = "A C S Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Biomimetic Phospholipid Membrane Organization on Graphene and Graphene Oxide Surfaces

T2 - A Molecular Dynamics Simulation Study

AU - Willems, Nathalie

AU - Urtizberea, Ainhoa

AU - Verre, Andrea F.

AU - Iliut, Maria

AU - Lelimousin, Mickael

AU - Hirtz, Michael

AU - Vijayaraghavan, Aravind

AU - Sansom, Mark S P

PY - 2017/2/6

Y1 - 2017/2/6

N2 - Supported phospholipid membrane patches stabilized on graphene surfaces have shown potential in sensor device functionalization, including biosensors and biocatalysis. Lipid dip-pen nanolithography (L-DPN) is a method useful in generating supported membrane structures that maintain lipid functionality, such as exhibiting specific interactions with protein molecules. Here, we have integrated L-DPN, atomic force microscopy, and coarse-grained molecular dynamics simulation methods to characterize the molecular properties of supported lipid membranes (SLMs) on graphene and graphene oxide supports. We observed substantial differences in the topologies of the stabilized lipid structures depending on the nature of the surface (polar graphene oxide vs nonpolar graphene). Furthermore, the addition of water to SLM systems resulted in large-scale reorganization of the lipid structures, with measurable effects on lipid lateral mobility within the supported membranes. We also observed reduced lipid ordering within the supported structures relative to free-standing lipid bilayers, attributed to the strong hydrophobic interactions between the lipids and support. Together, our results provide insight into the molecular effects of graphene and graphene oxide surfaces on lipid bilayer membranes. This will be important in the design of these surfaces for applications such as biosensor devices.

AB - Supported phospholipid membrane patches stabilized on graphene surfaces have shown potential in sensor device functionalization, including biosensors and biocatalysis. Lipid dip-pen nanolithography (L-DPN) is a method useful in generating supported membrane structures that maintain lipid functionality, such as exhibiting specific interactions with protein molecules. Here, we have integrated L-DPN, atomic force microscopy, and coarse-grained molecular dynamics simulation methods to characterize the molecular properties of supported lipid membranes (SLMs) on graphene and graphene oxide supports. We observed substantial differences in the topologies of the stabilized lipid structures depending on the nature of the surface (polar graphene oxide vs nonpolar graphene). Furthermore, the addition of water to SLM systems resulted in large-scale reorganization of the lipid structures, with measurable effects on lipid lateral mobility within the supported membranes. We also observed reduced lipid ordering within the supported structures relative to free-standing lipid bilayers, attributed to the strong hydrophobic interactions between the lipids and support. Together, our results provide insight into the molecular effects of graphene and graphene oxide surfaces on lipid bilayer membranes. This will be important in the design of these surfaces for applications such as biosensor devices.

KW - dip-pen nanolithography

KW - molecular dynamics

KW - phospholipid bilayer

KW - polymer pen lithography

KW - supported lipid membranes

UR - http://www.scopus.com/inward/record.url?scp=85014156947&partnerID=8YFLogxK

U2 - 10.1021/acsnano.6b07352

DO - 10.1021/acsnano.6b07352

M3 - Article

VL - 11

SP - 1613

EP - 1625

JO - A C S Nano

JF - A C S Nano

SN - 1936-0851

IS - 2

ER -