Bioinformatics for the synthetic biology of natural products: Integrating across the Design–Build–Test cycle

Research output: Contribution to journalArticle

  • External authors:
  • Andrew Currin
  • Nicholas Rattray
  • Neil Swainston
  • Cunyu Yan

Abstract

Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include tools for the selection, synthesis, assembly and optimization of parts (enzymes and regulatory elements), devices (pathways) and systems (chassis). TEST tools include those for screening, identification and quantification of metabolites for rapid prototyping. The main advantages and limitations of these tools as well as their interoperability capabilities are highlighted

Bibliographical metadata

Original languageEnglish
Pages (from-to)925-932
JournalNatural Product Reports
Volume33
Early online date17 May 2016
DOIs
StatePublished - 2016

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