Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

Research output: Contribution to journalArticle

  • External authors:
  • Bo Yuan
  • Abigail Page
  • Christopher P. Worrall
  • Franck Escalettes
  • Simon C. Willies
  • Jonathan Clayden

Abstract

All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Bibliographical metadata

Original languageEnglish
Pages (from-to)7010-7013
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number39
DOIs
Publication statusPublished - 17 Sep 2010

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