Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelorCitation formats

  • Authors:
  • Katharina G. Hugentobler
  • Humera Sharif
  • Marcello Rasparini
  • Rachel S. Heath
  • Nicholas J. Turner

Standard

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor. / Hugentobler, Katharina G.; Sharif, Humera; Rasparini, Marcello; Heath, Rachel S.; Turner, Nicholas J.

In: Organic and Biomolecular Chemistry, Vol. 14, No. 34, 2016, p. 8064-8067.

Research output: Contribution to journalArticle

Harvard

Hugentobler, KG, Sharif, H, Rasparini, M, Heath, RS & Turner, NJ 2016, 'Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor' Organic and Biomolecular Chemistry, vol. 14, no. 34, pp. 8064-8067. https://doi.org/10.1039/c6ob01382a

APA

Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S., & Turner, N. J. (2016). Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor. Organic and Biomolecular Chemistry, 14(34), 8064-8067. https://doi.org/10.1039/c6ob01382a

Vancouver

Hugentobler KG, Sharif H, Rasparini M, Heath RS, Turner NJ. Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor. Organic and Biomolecular Chemistry. 2016;14(34):8064-8067. https://doi.org/10.1039/c6ob01382a

Author

Hugentobler, Katharina G. ; Sharif, Humera ; Rasparini, Marcello ; Heath, Rachel S. ; Turner, Nicholas J. / Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor. In: Organic and Biomolecular Chemistry. 2016 ; Vol. 14, No. 34. pp. 8064-8067.

Bibtex

@article{4859971f9ac34e76888a4febb950a15f,
title = "Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor",
abstract = "Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst, the key building blocks for synthesis of the amine 2 were obtained in 99.9, 92.5 and 46.3 ee, respectively.",
author = "Hugentobler, {Katharina G.} and Humera Sharif and Marcello Rasparini and Heath, {Rachel S.} and Turner, {Nicholas J.}",
year = "2016",
doi = "10.1039/c6ob01382a",
language = "English",
volume = "14",
pages = "8064--8067",
journal = "Org Biomol Chem",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "34",

}

RIS

TY - JOUR

T1 - Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

AU - Hugentobler, Katharina G.

AU - Sharif, Humera

AU - Rasparini, Marcello

AU - Heath, Rachel S.

AU - Turner, Nicholas J.

PY - 2016

Y1 - 2016

N2 - Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst, the key building blocks for synthesis of the amine 2 were obtained in 99.9, 92.5 and 46.3 ee, respectively.

AB - Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst, the key building blocks for synthesis of the amine 2 were obtained in 99.9, 92.5 and 46.3 ee, respectively.

UR - http://www.scopus.com/inward/record.url?scp=84984656889&partnerID=8YFLogxK

U2 - 10.1039/c6ob01382a

DO - 10.1039/c6ob01382a

M3 - Article

VL - 14

SP - 8064

EP - 8067

JO - Org Biomol Chem

JF - Org Biomol Chem

SN - 1477-0520

IS - 34

ER -