Binding and interstitial penetration of liposomes within avascular tumor spheroids

Research output: Contribution to journalArticle

  • External authors:
  • D Emfietzoglou
  • A Papakostas
  • W.H. Yang
  • A. Ballangrud
  • G Sgouros

Abstract

The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.

Bibliographical metadata

Original languageEnglish
Pages (from-to)713-21
JournalInternational Journal of Cancer
Volume112
Issue number4
Publication statusPublished - 2004