Basic fibroblast growth factor: A potential new therapeutic tool for the treatment of hypertrophic and keloid scarsCitation formats

  • External authors:
  • Stephan Tiede
  • Nancy Ernst
  • Volker Tronnier
  • Christina Zechel

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Basic fibroblast growth factor: A potential new therapeutic tool for the treatment of hypertrophic and keloid scars. / Tiede, Stephan; Ernst, Nancy; Bayat, Ardeshir; Paus, Ralf; Tronnier, Volker; Zechel, Christina.

In: Annals of Anatomy, Vol. 191, No. 1, 01.2009, p. 33-44.

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Tiede, Stephan ; Ernst, Nancy ; Bayat, Ardeshir ; Paus, Ralf ; Tronnier, Volker ; Zechel, Christina. / Basic fibroblast growth factor: A potential new therapeutic tool for the treatment of hypertrophic and keloid scars. In: Annals of Anatomy. 2009 ; Vol. 191, No. 1. pp. 33-44.

Bibtex

@article{40f5ae20ba304a858f1ab1962c493f16,
title = "Basic fibroblast growth factor: A potential new therapeutic tool for the treatment of hypertrophic and keloid scars",
abstract = "Numerous tissue niches in the human body, such as skin, are now recognized to harbour adult stem cells. In this study, we analyze multipotent human dermis-derived progenitor cell populations, isolated and propagated from mechanically and enzymatically processed adult scalp skin. The populations encompass Nestin-positive and -negative cells, which may serve as a convenient and abundant source for various therapeutic applications in regenerative medicine. Here, we show that these cultures exhibit a strong tendency to differentiate into mesodermal derivatives, particularly myofibroblasts, when maintained in media containing serum. Since undesired and excessive myofibroblast formation is a frequent postsurgical complication, we sought culture conditions that would prevent myofibroblast formation. In particular, we analyzed the effect of growth factors, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor AB (PDGF AB). Our results demonstrate that bFGF is a potent inhibitor of mesodermal differentiation, whereas PDFG AB favours myofibroblast formation and up-regulates expression of TGFβ receptors I and II. This interesting discovery may help in the prevention and treatment of tissue fibrosis and in particular in the eradication of hypertrophic and keloid scars. {\textcopyright} 2008 Elsevier GmbH. All rights reserved.",
keywords = "Epidermal growth factor, Fibroblast growth factor, Hypertrophic scars, Keloid, Myofibroblast, Platelet-derived growth factor AB, Stem cells",
author = "Stephan Tiede and Nancy Ernst and Ardeshir Bayat and Ralf Paus and Volker Tronnier and Christina Zechel",
year = "2009",
month = jan,
doi = "10.1016/j.aanat.2008.10.001",
language = "English",
volume = "191",
pages = "33--44",
journal = "Annals of Anatomy",
issn = "0940-9602",
publisher = "Urban und Fischer Verlag GmbH",
number = "1",

}

RIS

TY - JOUR

T1 - Basic fibroblast growth factor: A potential new therapeutic tool for the treatment of hypertrophic and keloid scars

AU - Tiede, Stephan

AU - Ernst, Nancy

AU - Bayat, Ardeshir

AU - Paus, Ralf

AU - Tronnier, Volker

AU - Zechel, Christina

PY - 2009/1

Y1 - 2009/1

N2 - Numerous tissue niches in the human body, such as skin, are now recognized to harbour adult stem cells. In this study, we analyze multipotent human dermis-derived progenitor cell populations, isolated and propagated from mechanically and enzymatically processed adult scalp skin. The populations encompass Nestin-positive and -negative cells, which may serve as a convenient and abundant source for various therapeutic applications in regenerative medicine. Here, we show that these cultures exhibit a strong tendency to differentiate into mesodermal derivatives, particularly myofibroblasts, when maintained in media containing serum. Since undesired and excessive myofibroblast formation is a frequent postsurgical complication, we sought culture conditions that would prevent myofibroblast formation. In particular, we analyzed the effect of growth factors, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor AB (PDGF AB). Our results demonstrate that bFGF is a potent inhibitor of mesodermal differentiation, whereas PDFG AB favours myofibroblast formation and up-regulates expression of TGFβ receptors I and II. This interesting discovery may help in the prevention and treatment of tissue fibrosis and in particular in the eradication of hypertrophic and keloid scars. © 2008 Elsevier GmbH. All rights reserved.

AB - Numerous tissue niches in the human body, such as skin, are now recognized to harbour adult stem cells. In this study, we analyze multipotent human dermis-derived progenitor cell populations, isolated and propagated from mechanically and enzymatically processed adult scalp skin. The populations encompass Nestin-positive and -negative cells, which may serve as a convenient and abundant source for various therapeutic applications in regenerative medicine. Here, we show that these cultures exhibit a strong tendency to differentiate into mesodermal derivatives, particularly myofibroblasts, when maintained in media containing serum. Since undesired and excessive myofibroblast formation is a frequent postsurgical complication, we sought culture conditions that would prevent myofibroblast formation. In particular, we analyzed the effect of growth factors, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor AB (PDGF AB). Our results demonstrate that bFGF is a potent inhibitor of mesodermal differentiation, whereas PDFG AB favours myofibroblast formation and up-regulates expression of TGFβ receptors I and II. This interesting discovery may help in the prevention and treatment of tissue fibrosis and in particular in the eradication of hypertrophic and keloid scars. © 2008 Elsevier GmbH. All rights reserved.

KW - Epidermal growth factor

KW - Fibroblast growth factor

KW - Hypertrophic scars

KW - Keloid

KW - Myofibroblast

KW - Platelet-derived growth factor AB

KW - Stem cells

U2 - 10.1016/j.aanat.2008.10.001

DO - 10.1016/j.aanat.2008.10.001

M3 - Article

C2 - 19071002

VL - 191

SP - 33

EP - 44

JO - Annals of Anatomy

JF - Annals of Anatomy

SN - 0940-9602

IS - 1

ER -