Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthmaCitation formats

  • External authors:
  • Bede Constantinides
  • Paraskevi Xepapadaki

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Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma. / Megremis, Spyridon; Constantinides, Bede; Xepapadaki, Paraskevi; Robertson, David; Papadopoulos, Nikolaos; Tapinos, Avraam.

In: bioRxiv, 04.08.2020.

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@article{9543307b541b4bfdb835eacdb813d414,
title = "Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma",
abstract = "Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.",
author = "Spyridon Megremis and Bede Constantinides and Paraskevi Xepapadaki and David Robertson and Nikolaos Papadopoulos and Avraam Tapinos",
year = "2020",
month = aug,
day = "4",
doi = "https://doi.org/10.1101/2020.08.04.236067",
language = "English",
journal = "bioRxiv",
issn = "2692-8205",
publisher = "Cold Spring Harbor Laboratory Press",

}

RIS

TY - JOUR

T1 - Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma

AU - Megremis, Spyridon

AU - Constantinides, Bede

AU - Xepapadaki, Paraskevi

AU - Robertson, David

AU - Papadopoulos, Nikolaos

AU - Tapinos, Avraam

PY - 2020/8/4

Y1 - 2020/8/4

N2 - Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.

AB - Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.

U2 - https://doi.org/10.1101/2020.08.04.236067

DO - https://doi.org/10.1101/2020.08.04.236067

M3 - Article

JO - bioRxiv

JF - bioRxiv

SN - 2692-8205

ER -