Bacteriophage deficiency characterizes respiratory virome dysbiosis in childhood asthma

Research output: Contribution to journalArticle

  • External authors:
  • Bede Constantinides
  • Paraskevi Xepapadaki

Abstract

Asthma development and persistence is tightly linked to respiratory viruses. Viral presence is usually interrogated with targeted approaches during periods of disease activity and/or infections, thus neglecting viral occurrence during steady states. We investigate the virome in the upper respiratory system of healthy and asthmatic preschool children during asymptomatic/non-infection periods using metagenomics. Children with asthma have a characteristically dysbiotic virome that correlates to disease severity and control. The major component of dysbiosis is bacteriophage deficiency, while eukaryotic viral presence is increased. At the metacommunity level, differential virus species co-occurrence patterns suggest a decrease of the microbiota community resilience in asthma. Viral dysbiosis is therefore a key characteristic of asthma pathophysiology.

Bibliographical metadata

Original languageEnglish
JournalbioRxiv
DOIs
Publication statusPublished - 4 Aug 2020