Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging

Research output: Contribution to journalArticle

Abstract

Highly hydrophilic hollow polycaprolactone (PCL) microfibres were developed as building elements to create tissue-mimicking test objects (phantoms) for validation of diffusion magnetic resonance imaging (MRI). These microfibres were fabricated by the co-electrospinning of PCL-polysiloxanebased
surfactant (PSi) mixture as shell and polyethylene oxide as core. The addition of PSi had a significant effect on the size of resultant electrospun fibres and the formation of hollow microfibres. The presence of PSi in both co-electrospun PCL microfibre surface and cross-section, revealed by Xray energy dispersive spectroscopy (EDX), enabled water to wet these fibres completely (i.e., zero
contact angle) and remained active for up to 12 months after immersing in water. PCL and PCL-PSi fibres with uniaxial orientation were constructed into water-filled phantoms. MR measurement revealed that water molecules diffuse anisotropically in the PCL-PSi phantom. Co-electrospun hollow PCL-PSi microfibres have desirable hydrophilic properties for the construction of a new
generation of tissue-mimicking dMRI phantoms.

Bibliographical metadata

Original languageEnglish
JournalMaterials & Design
Volume137
Early online date16 Oct 2017
DOIs
StatePublished - 5 Jan 2018