Attoliter Chemistry for Nano-Scale Functionalization of Graphene

Research output: Contribution to journalArticle


The nanoscale, multiplexed functionalization of graphene in a device array is a critical step to realize graphene-based chemical and biosensors. We demonstrate that graphene can be functionalized with submicron resolution and in well-defined locations and patterns using reaction agents in attoliter quantities, utilizing dip-pen nanolithography or microchannel cantilever spotting. Specifically, we functionalize graphene with a biotin azide using click-chemistry and demonstrate the subsequent binding of fluorescently tagged streptavidin. The technique can be scaled up to multiplex functionalize graphene devices on a wafer-scale for sensor and biomedical applications.

Bibliographical metadata

Original languageEnglish
Pages (from-to)33371-33376
Number of pages6
JournalACS Applied Materials and Interfaces
Early online date30 Nov 2016
StatePublished - 14 Dec 2016