Association of metabolic gene polymorphisms with alcohol consumption in controlsCitation formats

  • External authors:
  • S. Raimondi
  • S. Benhamou
  • C. Coutelle
  • S. Garte
  • R. Hayes
  • L. Kiemeney
  • P. Lazarus
  • L. Le Marchand
  • S. Morita
  • M. Romkes
  • A. Zijno
  • Emanuela Taioli

Standard

Association of metabolic gene polymorphisms with alcohol consumption in controls. / Raimondi, S.; Benhamou, S.; Coutelle, C.; Garte, S.; Hayes, R.; Kiemeney, L.; Lazarus, P.; Le Marchand, L.; Morita, S.; Povey, A.; Romkes, M.; Zijno, A.; Taioli, Emanuela.

In: Biomarkers, Vol. 9, No. 2, 03.2004, p. 180-189.

Research output: Contribution to journalArticle

Harvard

Raimondi, S, Benhamou, S, Coutelle, C, Garte, S, Hayes, R, Kiemeney, L, Lazarus, P, Le Marchand, L, Morita, S, Povey, A, Romkes, M, Zijno, A & Taioli, E 2004, 'Association of metabolic gene polymorphisms with alcohol consumption in controls', Biomarkers, vol. 9, no. 2, pp. 180-189. https://doi.org/10.1080/13547500410001728381

APA

Raimondi, S., Benhamou, S., Coutelle, C., Garte, S., Hayes, R., Kiemeney, L., ... Taioli, E. (2004). Association of metabolic gene polymorphisms with alcohol consumption in controls. Biomarkers, 9(2), 180-189. https://doi.org/10.1080/13547500410001728381

Vancouver

Raimondi S, Benhamou S, Coutelle C, Garte S, Hayes R, Kiemeney L et al. Association of metabolic gene polymorphisms with alcohol consumption in controls. Biomarkers. 2004 Mar;9(2):180-189. https://doi.org/10.1080/13547500410001728381

Author

Raimondi, S. ; Benhamou, S. ; Coutelle, C. ; Garte, S. ; Hayes, R. ; Kiemeney, L. ; Lazarus, P. ; Le Marchand, L. ; Morita, S. ; Povey, A. ; Romkes, M. ; Zijno, A. ; Taioli, Emanuela. / Association of metabolic gene polymorphisms with alcohol consumption in controls. In: Biomarkers. 2004 ; Vol. 9, No. 2. pp. 180-189.

Bibtex

@article{c5fab7fedf6f4a20b0a894d40aa9292a,
title = "Association of metabolic gene polymorphisms with alcohol consumption in controls",
abstract = "The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls. Healthy subjects were selected from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Subjects with information on both alcohol consumption and at least one of the studied polymorphisms were included in the analysis (n= 2224). Information on the amount of alcohol consumption was available for a subset of subjects (n =844). None of the studied genes was significantly associated with drinking habits. A significant heterogeneity with age was observed when studying the association between CYP2E1 RsaI and alcohol drinking. CYP2E1 RsaI polymorphism was significantly associated with being a never drinker at older ages (odds ratio [OR] 2.4, 95{\%} confidence interval [CI] 1.2-4.8; at ages above 68 years), while the association was reversed at ages below 47 years (OR 0.5, 95{\%} CI 0.2-1.4). For subjects with detailed information on alcohol intake, no association between alcohol quantity and polymorphisms in metabolic genes was observed; subjects carrying the NQO1 polymorphism tended to drink more than subjects carrying the wild-type alleles. Therefore, no significant association between CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1 polymorphisms and alcohol consumption was observed in healthy controls. {\circledC} 2004 Taylor & Francis Ltd.",
keywords = "Diet, Epidemiology, Pooled analysis",
author = "S. Raimondi and S. Benhamou and C. Coutelle and S. Garte and R. Hayes and L. Kiemeney and P. Lazarus and {Le Marchand}, L. and S. Morita and A. Povey and M. Romkes and A. Zijno and Emanuela Taioli",
year = "2004",
month = "3",
doi = "10.1080/13547500410001728381",
language = "English",
volume = "9",
pages = "180--189",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Informa Healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - Association of metabolic gene polymorphisms with alcohol consumption in controls

AU - Raimondi, S.

AU - Benhamou, S.

AU - Coutelle, C.

AU - Garte, S.

AU - Hayes, R.

AU - Kiemeney, L.

AU - Lazarus, P.

AU - Le Marchand, L.

AU - Morita, S.

AU - Povey, A.

AU - Romkes, M.

AU - Zijno, A.

AU - Taioli, Emanuela

PY - 2004/3

Y1 - 2004/3

N2 - The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls. Healthy subjects were selected from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Subjects with information on both alcohol consumption and at least one of the studied polymorphisms were included in the analysis (n= 2224). Information on the amount of alcohol consumption was available for a subset of subjects (n =844). None of the studied genes was significantly associated with drinking habits. A significant heterogeneity with age was observed when studying the association between CYP2E1 RsaI and alcohol drinking. CYP2E1 RsaI polymorphism was significantly associated with being a never drinker at older ages (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.2-4.8; at ages above 68 years), while the association was reversed at ages below 47 years (OR 0.5, 95% CI 0.2-1.4). For subjects with detailed information on alcohol intake, no association between alcohol quantity and polymorphisms in metabolic genes was observed; subjects carrying the NQO1 polymorphism tended to drink more than subjects carrying the wild-type alleles. Therefore, no significant association between CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1 polymorphisms and alcohol consumption was observed in healthy controls. © 2004 Taylor & Francis Ltd.

AB - The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls. Healthy subjects were selected from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Subjects with information on both alcohol consumption and at least one of the studied polymorphisms were included in the analysis (n= 2224). Information on the amount of alcohol consumption was available for a subset of subjects (n =844). None of the studied genes was significantly associated with drinking habits. A significant heterogeneity with age was observed when studying the association between CYP2E1 RsaI and alcohol drinking. CYP2E1 RsaI polymorphism was significantly associated with being a never drinker at older ages (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.2-4.8; at ages above 68 years), while the association was reversed at ages below 47 years (OR 0.5, 95% CI 0.2-1.4). For subjects with detailed information on alcohol intake, no association between alcohol quantity and polymorphisms in metabolic genes was observed; subjects carrying the NQO1 polymorphism tended to drink more than subjects carrying the wild-type alleles. Therefore, no significant association between CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1 polymorphisms and alcohol consumption was observed in healthy controls. © 2004 Taylor & Francis Ltd.

KW - Diet

KW - Epidemiology

KW - Pooled analysis

U2 - 10.1080/13547500410001728381

DO - 10.1080/13547500410001728381

M3 - Article

VL - 9

SP - 180

EP - 189

JO - Biomarkers

T2 - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 2

ER -