Arginase signalling as a key player in chronic wound pathophysiology and healingCitation formats

Standard

Arginase signalling as a key player in chronic wound pathophysiology and healing. / Szondi, Denis; Wong, Jason; Vardy, Leah A.; Cruickshank, Sheena.

In: Frontiers in Molecular Biosciences, 14.10.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Szondi, D., Wong, J., Vardy, L. A., & Cruickshank, S. (Accepted/In press). Arginase signalling as a key player in chronic wound pathophysiology and healing. Frontiers in Molecular Biosciences.

Vancouver

Szondi D, Wong J, Vardy LA, Cruickshank S. Arginase signalling as a key player in chronic wound pathophysiology and healing. Frontiers in Molecular Biosciences. 2021 Oct 14.

Author

Szondi, Denis ; Wong, Jason ; Vardy, Leah A. ; Cruickshank, Sheena. / Arginase signalling as a key player in chronic wound pathophysiology and healing. In: Frontiers in Molecular Biosciences. 2021.

Bibtex

@article{202098e2d1ca4a3c84b9fd1f70bba26d,
title = "Arginase signalling as a key player in chronic wound pathophysiology and healing",
abstract = "Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeostatic conditions through the production of L-ornithine and urea. L-ornithine represents the intersection point between the ARG-dependent pathways and the urea cycle, therefore contributing to cell detoxification, proliferation and collagen production. The ARG pathways help balance pro- and anti-inflammatory responses in the context of wound healing. However, local and systemic dysfunctionalities of the ARG pathways have been shown to contribute to the hindrance of the healing process and the occurrence of chronic wounds. This review discusses the functions of ARG in macrophages and fibroblasts while detailing the deleterious implications of a malfunctioning ARG enzyme in chronic skin conditions such as leg ulcers. The review also highlights how ARG links with the microbiota and how this impacts on infected chronic wounds. Lastly, the review depicts chronic wound treatments targeting the ARG pathway, alongside future diagnosis and treatment perspectives.",
author = "Denis Szondi and Jason Wong and Vardy, {Leah A.} and Sheena Cruickshank",
year = "2021",
month = oct,
day = "14",
language = "English",
journal = "Frontiers in Molecular Biosciences",
issn = "2296-889X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Arginase signalling as a key player in chronic wound pathophysiology and healing

AU - Szondi, Denis

AU - Wong, Jason

AU - Vardy, Leah A.

AU - Cruickshank, Sheena

PY - 2021/10/14

Y1 - 2021/10/14

N2 - Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeostatic conditions through the production of L-ornithine and urea. L-ornithine represents the intersection point between the ARG-dependent pathways and the urea cycle, therefore contributing to cell detoxification, proliferation and collagen production. The ARG pathways help balance pro- and anti-inflammatory responses in the context of wound healing. However, local and systemic dysfunctionalities of the ARG pathways have been shown to contribute to the hindrance of the healing process and the occurrence of chronic wounds. This review discusses the functions of ARG in macrophages and fibroblasts while detailing the deleterious implications of a malfunctioning ARG enzyme in chronic skin conditions such as leg ulcers. The review also highlights how ARG links with the microbiota and how this impacts on infected chronic wounds. Lastly, the review depicts chronic wound treatments targeting the ARG pathway, alongside future diagnosis and treatment perspectives.

AB - Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeostatic conditions through the production of L-ornithine and urea. L-ornithine represents the intersection point between the ARG-dependent pathways and the urea cycle, therefore contributing to cell detoxification, proliferation and collagen production. The ARG pathways help balance pro- and anti-inflammatory responses in the context of wound healing. However, local and systemic dysfunctionalities of the ARG pathways have been shown to contribute to the hindrance of the healing process and the occurrence of chronic wounds. This review discusses the functions of ARG in macrophages and fibroblasts while detailing the deleterious implications of a malfunctioning ARG enzyme in chronic skin conditions such as leg ulcers. The review also highlights how ARG links with the microbiota and how this impacts on infected chronic wounds. Lastly, the review depicts chronic wound treatments targeting the ARG pathway, alongside future diagnosis and treatment perspectives.

M3 - Article

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

SN - 2296-889X

ER -