Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants.Citation formats

Standard

Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants. / Pobric, Gorana; Jefferies, Elizabeth; Ralph, Matthew A Lambon.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 50, 11.12.2007, p. 20137-20141.

Research output: Contribution to journalArticle

Harvard

Pobric, G, Jefferies, E & Ralph, MAL 2007, 'Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants.', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 50, pp. 20137-20141. https://doi.org/10.1073/pnas.0707383104

APA

Pobric, G., Jefferies, E., & Ralph, M. A. L. (2007). Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants. Proceedings of the National Academy of Sciences of the United States of America, 104(50), 20137-20141. https://doi.org/10.1073/pnas.0707383104

Vancouver

Pobric G, Jefferies E, Ralph MAL. Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants. Proceedings of the National Academy of Sciences of the United States of America. 2007 Dec 11;104(50):20137-20141. https://doi.org/10.1073/pnas.0707383104

Author

Pobric, Gorana ; Jefferies, Elizabeth ; Ralph, Matthew A Lambon. / Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 50. pp. 20137-20141.

Bibtex

@article{0e416511dd1f44da978244f38ceaa221,
title = "Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants.",
abstract = "Studies of semantic dementia and PET neuroimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation (rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.",
keywords = "Repetitive transcranial magnetic stimulation, Semantic cognition, Temporal pole",
author = "Gorana Pobric and Elizabeth Jefferies and Ralph, {Matthew A Lambon}",
note = "078734/Z/05/Z, Wellcome Trust, United KingdomG0501632, Medical Research Council, United Kingdom",
year = "2007",
month = "12",
day = "11",
doi = "10.1073/pnas.0707383104",
language = "English",
volume = "104",
pages = "20137--20141",
journal = "Proceedings of the National Academy of Sciences",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "50",

}

RIS

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T1 - Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants.

AU - Pobric, Gorana

AU - Jefferies, Elizabeth

AU - Ralph, Matthew A Lambon

N1 - 078734/Z/05/Z, Wellcome Trust, United KingdomG0501632, Medical Research Council, United Kingdom

PY - 2007/12/11

Y1 - 2007/12/11

N2 - Studies of semantic dementia and PET neuroimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation (rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.

AB - Studies of semantic dementia and PET neuroimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation (rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.

KW - Repetitive transcranial magnetic stimulation

KW - Semantic cognition

KW - Temporal pole

U2 - 10.1073/pnas.0707383104

DO - 10.1073/pnas.0707383104

M3 - Article

VL - 104

SP - 20137

EP - 20141

JO - Proceedings of the National Academy of Sciences

T2 - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 0027-8424

IS - 50

ER -