Anterior temporal lobes mediate semantic representation: mimicking semantic dementia by using rTMS in normal participants.

Research output: Contribution to journalArticle

Abstract

Studies of semantic dementia and PET neuroimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation (rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.

Bibliographical metadata

Original languageEnglish
Pages (from-to)20137-20141
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number50
DOIs
Publication statusPublished - 11 Dec 2007