Analytical expressions for combining population pharmacokinetic parameters from different studiesCitation formats

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Analytical expressions for combining population pharmacokinetic parameters from different studies. / Dokoumetzidis, Aristides; Aarons, Leon.

In: Journal of Biopharmaceutical Statistics, Vol. 18, No. 4, 07.2008, p. 662-676.

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Dokoumetzidis, Aristides ; Aarons, Leon. / Analytical expressions for combining population pharmacokinetic parameters from different studies. In: Journal of Biopharmaceutical Statistics. 2008 ; Vol. 18, No. 4. pp. 662-676.

Bibtex

@article{8c6c8a51d0a84b03a8cca4fb0aeac228,
title = "Analytical expressions for combining population pharmacokinetic parameters from different studies",
abstract = "We provide a set of formulas that allow the combination of separately performed analyses of population pharmacokinetic (PK) studies, without any further computational effort. More specifically, given the point estimates and uncertainties of two population PK analyses, the formulas provide the point estimates and uncertainties of the combined analysis, including the mean population values, the between-subject variability, and the residual variability. To derive the formulas we considered distributional assumptions applicable for the conjugate priors of the Bayesian problem of {"}unknown mean and variance.{"} In order to demonstrate the approach, the formulas were applied to an example involving the results of fitting two real experimental datasets. The formulas presented offer an easy-to-use method of combining different analyses particularly applicable to a combination of literature information. Copyright {\circledC} Taylor & Francis Group, LLC.",
keywords = "Bayesian analysis, Population pharmacokinetics, Weighted mean",
author = "Aristides Dokoumetzidis and Leon Aarons",
year = "2008",
month = "7",
doi = "10.1080/10543400802071360",
language = "English",
volume = "18",
pages = "662--676",
journal = "Journal of Biopharmaceutical Statistics",
issn = "1054-3406",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Analytical expressions for combining population pharmacokinetic parameters from different studies

AU - Dokoumetzidis, Aristides

AU - Aarons, Leon

PY - 2008/7

Y1 - 2008/7

N2 - We provide a set of formulas that allow the combination of separately performed analyses of population pharmacokinetic (PK) studies, without any further computational effort. More specifically, given the point estimates and uncertainties of two population PK analyses, the formulas provide the point estimates and uncertainties of the combined analysis, including the mean population values, the between-subject variability, and the residual variability. To derive the formulas we considered distributional assumptions applicable for the conjugate priors of the Bayesian problem of "unknown mean and variance." In order to demonstrate the approach, the formulas were applied to an example involving the results of fitting two real experimental datasets. The formulas presented offer an easy-to-use method of combining different analyses particularly applicable to a combination of literature information. Copyright © Taylor & Francis Group, LLC.

AB - We provide a set of formulas that allow the combination of separately performed analyses of population pharmacokinetic (PK) studies, without any further computational effort. More specifically, given the point estimates and uncertainties of two population PK analyses, the formulas provide the point estimates and uncertainties of the combined analysis, including the mean population values, the between-subject variability, and the residual variability. To derive the formulas we considered distributional assumptions applicable for the conjugate priors of the Bayesian problem of "unknown mean and variance." In order to demonstrate the approach, the formulas were applied to an example involving the results of fitting two real experimental datasets. The formulas presented offer an easy-to-use method of combining different analyses particularly applicable to a combination of literature information. Copyright © Taylor & Francis Group, LLC.

KW - Bayesian analysis

KW - Population pharmacokinetics

KW - Weighted mean

U2 - 10.1080/10543400802071360

DO - 10.1080/10543400802071360

M3 - Article

VL - 18

SP - 662

EP - 676

JO - Journal of Biopharmaceutical Statistics

JF - Journal of Biopharmaceutical Statistics

SN - 1054-3406

IS - 4

ER -