Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphateCitation formats

  • External authors:
  • Emaan Alsubhe
  • Mozhdeh Mehrabi
  • El Mostafa Raif
  • Ali Hassanpour
  • Peter Giannoudis
  • Animesh Jha

Standard

Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate. / Alsubhe, Emaan; Anastasiou, Antonios D.; Mehrabi, Mozhdeh; Raif, El Mostafa; Hassanpour, Ali; Giannoudis, Peter; Jha, Animesh.

In: Materials Science and Engineering C, Vol. 115, 111053, 01.10.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Alsubhe, E, Anastasiou, AD, Mehrabi, M, Raif, EM, Hassanpour, A, Giannoudis, P & Jha, A 2020, 'Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate', Materials Science and Engineering C, vol. 115, 111053. https://doi.org/10.1016/j.msec.2020.111053

APA

Alsubhe, E., Anastasiou, A. D., Mehrabi, M., Raif, E. M., Hassanpour, A., Giannoudis, P., & Jha, A. (2020). Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate. Materials Science and Engineering C, 115, [111053]. https://doi.org/10.1016/j.msec.2020.111053

Vancouver

Alsubhe E, Anastasiou AD, Mehrabi M, Raif EM, Hassanpour A, Giannoudis P et al. Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate. Materials Science and Engineering C. 2020 Oct 1;115. 111053. https://doi.org/10.1016/j.msec.2020.111053

Author

Alsubhe, Emaan ; Anastasiou, Antonios D. ; Mehrabi, Mozhdeh ; Raif, El Mostafa ; Hassanpour, Ali ; Giannoudis, Peter ; Jha, Animesh. / Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate. In: Materials Science and Engineering C. 2020 ; Vol. 115.

Bibtex

@article{bd17aa78f5d14294b97b31df001ae0ee,
title = "Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate",
abstract = "The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO4·2H2O) has been investigated for osteogenic potential and mechanical properties. The synthesis of iron-oxide doping in the form of Fe2+,3+-ions were carried out using the solution based method in which the ammonium hydrogen phosphate and calcium nitrate solutions were used in stoichiometric ratio for synthesizing CaHPO4·2H2O, with doping concentrations of Fe2+,3+-ions between 5 mol% and 30 mol%. The synthesized powders were analysed using X-ray powder diffraction, FTIR, SEM and Raman spectroscopic techniques. The heat treatment of synthesized powder was carried out at 1000 °C in air for 5 h, and it was found that the dominant crystalline phase in samples with <20 mol% was β-CPP, which also formed an iron-rich solid solution phase. Increasing the concentrations of Fe2+,3+-ions enhances the phase fraction of FePO4 and amorphous phase. Amongst the Fe2+,3+-doped β-CPP minerals, it was found that the 10 mol% Fe2+,3+-doped β-CPP offers the best combination of bio-mechanical and osteogenic properties as a scaffold for bone tissue regenerative engineering.",
keywords = "Brushite, Iron phosphate, Mechanical properties, Osteogenic cells, β‑calcium pyrophosphate",
author = "Emaan Alsubhe and Anastasiou, {Antonios D.} and Mozhdeh Mehrabi and Raif, {El Mostafa} and Ali Hassanpour and Peter Giannoudis and Animesh Jha",
year = "2020",
month = oct,
day = "1",
doi = "10.1016/j.msec.2020.111053",
language = "English",
volume = "115",
journal = "Materials Science and Engineering C: Materials for Biological Applications ",
issn = "0928-4931",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate

AU - Alsubhe, Emaan

AU - Anastasiou, Antonios D.

AU - Mehrabi, Mozhdeh

AU - Raif, El Mostafa

AU - Hassanpour, Ali

AU - Giannoudis, Peter

AU - Jha, Animesh

PY - 2020/10/1

Y1 - 2020/10/1

N2 - The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO4·2H2O) has been investigated for osteogenic potential and mechanical properties. The synthesis of iron-oxide doping in the form of Fe2+,3+-ions were carried out using the solution based method in which the ammonium hydrogen phosphate and calcium nitrate solutions were used in stoichiometric ratio for synthesizing CaHPO4·2H2O, with doping concentrations of Fe2+,3+-ions between 5 mol% and 30 mol%. The synthesized powders were analysed using X-ray powder diffraction, FTIR, SEM and Raman spectroscopic techniques. The heat treatment of synthesized powder was carried out at 1000 °C in air for 5 h, and it was found that the dominant crystalline phase in samples with <20 mol% was β-CPP, which also formed an iron-rich solid solution phase. Increasing the concentrations of Fe2+,3+-ions enhances the phase fraction of FePO4 and amorphous phase. Amongst the Fe2+,3+-doped β-CPP minerals, it was found that the 10 mol% Fe2+,3+-doped β-CPP offers the best combination of bio-mechanical and osteogenic properties as a scaffold for bone tissue regenerative engineering.

AB - The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO4·2H2O) has been investigated for osteogenic potential and mechanical properties. The synthesis of iron-oxide doping in the form of Fe2+,3+-ions were carried out using the solution based method in which the ammonium hydrogen phosphate and calcium nitrate solutions were used in stoichiometric ratio for synthesizing CaHPO4·2H2O, with doping concentrations of Fe2+,3+-ions between 5 mol% and 30 mol%. The synthesized powders were analysed using X-ray powder diffraction, FTIR, SEM and Raman spectroscopic techniques. The heat treatment of synthesized powder was carried out at 1000 °C in air for 5 h, and it was found that the dominant crystalline phase in samples with <20 mol% was β-CPP, which also formed an iron-rich solid solution phase. Increasing the concentrations of Fe2+,3+-ions enhances the phase fraction of FePO4 and amorphous phase. Amongst the Fe2+,3+-doped β-CPP minerals, it was found that the 10 mol% Fe2+,3+-doped β-CPP offers the best combination of bio-mechanical and osteogenic properties as a scaffold for bone tissue regenerative engineering.

KW - Brushite

KW - Iron phosphate

KW - Mechanical properties

KW - Osteogenic cells

KW - β‑calcium pyrophosphate

U2 - 10.1016/j.msec.2020.111053

DO - 10.1016/j.msec.2020.111053

M3 - Article

C2 - 32600686

AN - SCOPUS:85086498289

VL - 115

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

SN - 0928-4931

M1 - 111053

ER -