An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence

Research output: Contribution to journalArticle

  • External authors:
  • Miles H. Aukland
  • Fabien J. T. Talbot
  • José A. Fernández-salas
  • Matthew Ball

Abstract

An interrupted Pummerer/nickel‐catalysed cross‐coupling strategy has been developed and used in the elaboration of styrenes. The operationally simple method can be carried out as a one‐pot process, involves the direct formation of stable alkenyl sulfonium salt intermediates, utilises a commercially available sulfoxide, catalyst, and ligand, operates at ambient temperature, accommodates sp‐, sp2‐, and sp3‐hybridised organozinc coupling partners, and delivers functionalised styrene products in high yields over two steps. An interrupted Pummerer/cyclisation approach has also been used to access carbo‐ and heterocyclic alkenyl sulfonium salts for cross‐coupling.

Bibliographical metadata

Original languageEnglish
JournalAngewandte Chemie International Edition
Volume57
Issue number31
Early online date8 Jun 2018
DOIs
Publication statusPublished - 26 Jul 2018

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