An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

Research output: Contribution to journalArticle

  • External authors:
  • N. D. Adams
  • K. R. Godfrey
  • M. J. Chapman
  • M. J. Chappell
  • S. B. Duffull

Abstract

The paper considers the structural identifiability of a parent-metabolite pharmacokinetic model for ivabradine and one of its metabolites. The model, which is linear, is considered initially for intravenous administration of ivabradine, and then for a combined intravenous and oral administration. In both cases, the model is shown to be unidentifiable. Simplification of the model (for both forms of administration) to that proposed by Duffull et al. (1) results in a globally structurally identifiable model. The analysis could be applied to the modeling of any drug undergoing first-pass metabolism, with plasma concentrations available from drug and metabolite.

Bibliographical metadata

Original languageEnglish
Pages (from-to)93-105
Number of pages12
JournalJournal of pharmacokinetics and pharmacodynamics
Volume28
Issue number1
DOIs
Publication statusPublished - 2001