Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasisCitation formats

  • External authors:
  • Siddharth Krishnan
  • Ian Prise
  • Kelly Wemyss
  • Louis Schenck
  • Hayley Bridgeman
  • Flora Mcclure
  • Tamsin Zangerle Murray
  • Conor O'Boyle
  • Thomas Barbera
  • Faiza Mahmood
  • Dawn. M. E Bowdish
  • Dietmar M Zaiss

Standard

Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis. / Krishnan, Siddharth; Prise, Ian; Wemyss, Kelly; Schenck, Louis; Bridgeman, Hayley; Mcclure, Flora; Zangerle Murray, Tamsin; O'Boyle, Conor; Barbera, Thomas; Mahmood, Faiza ; Bowdish, Dawn. M. E; Zaiss, Dietmar M; Grainger, John; Konkel, Joanne.

In: Proceedings of the National Academy of Sciences, Vol. 115, No. 42, 16.10.2018, p. 10738-10743.

Research output: Contribution to journalArticle

Harvard

Krishnan, S, Prise, I, Wemyss, K, Schenck, L, Bridgeman, H, Mcclure, F, Zangerle Murray, T, O'Boyle, C, Barbera, T, Mahmood, F, Bowdish, DME, Zaiss, DM, Grainger, J & Konkel, J 2018, 'Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis' Proceedings of the National Academy of Sciences, vol. 115, no. 42, pp. 10738-10743. https://doi.org/10.1073/pnas.1802320115

APA

Krishnan, S., Prise, I., Wemyss, K., Schenck, L., Bridgeman, H., Mcclure, F., ... Konkel, J. (2018). Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis. Proceedings of the National Academy of Sciences, 115(42), 10738-10743. https://doi.org/10.1073/pnas.1802320115

Vancouver

Krishnan S, Prise I, Wemyss K, Schenck L, Bridgeman H, Mcclure F et al. Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis. Proceedings of the National Academy of Sciences. 2018 Oct 16;115(42):10738-10743. https://doi.org/10.1073/pnas.1802320115

Author

Krishnan, Siddharth ; Prise, Ian ; Wemyss, Kelly ; Schenck, Louis ; Bridgeman, Hayley ; Mcclure, Flora ; Zangerle Murray, Tamsin ; O'Boyle, Conor ; Barbera, Thomas ; Mahmood, Faiza ; Bowdish, Dawn. M. E ; Zaiss, Dietmar M ; Grainger, John ; Konkel, Joanne. / Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis. In: Proceedings of the National Academy of Sciences. 2018 ; Vol. 115, No. 42. pp. 10738-10743.

Bibtex

@article{07385fe46bf74e579fb830137b29bb49,
title = "Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis",
abstract = "γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival γδ T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced pathology inmurine models of the oral inflammatory disease periodontitis. Alterations in bacterial communities could not account for the increased disease severity seen in γδ T cell-deficient mice. Instead, gingival γδ T cells produced the wound healing associated cytokine amphiregulin, administration of which rescued the elevated oral pathology of tcrδ -/- mice. Collectively, our results identify γδ T cells as critical constituents of the immuno-surveillance network that safeguard gingival tissue homeostasis.",
keywords = "Amphiregulin, Mucosal immunology, γδ T cells",
author = "Siddharth Krishnan and Ian Prise and Kelly Wemyss and Louis Schenck and Hayley Bridgeman and Flora Mcclure and {Zangerle Murray}, Tamsin and Conor O'Boyle and Thomas Barbera and Faiza Mahmood and Bowdish, {Dawn. M. E} and Zaiss, {Dietmar M} and John Grainger and Joanne Konkel",
year = "2018",
month = "10",
day = "16",
doi = "10.1073/pnas.1802320115",
language = "English",
volume = "115",
pages = "10738--10743",
journal = "Proceedings of the National Academy of Sciences",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "42",

}

RIS

TY - JOUR

T1 - Amphiregulin producing γδ T cells are vital for safeguarding oral barrier immune homeostasis

AU - Krishnan, Siddharth

AU - Prise, Ian

AU - Wemyss, Kelly

AU - Schenck, Louis

AU - Bridgeman, Hayley

AU - Mcclure, Flora

AU - Zangerle Murray, Tamsin

AU - O'Boyle, Conor

AU - Barbera, Thomas

AU - Mahmood, Faiza

AU - Bowdish, Dawn. M. E

AU - Zaiss, Dietmar M

AU - Grainger, John

AU - Konkel, Joanne

PY - 2018/10/16

Y1 - 2018/10/16

N2 - γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival γδ T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced pathology inmurine models of the oral inflammatory disease periodontitis. Alterations in bacterial communities could not account for the increased disease severity seen in γδ T cell-deficient mice. Instead, gingival γδ T cells produced the wound healing associated cytokine amphiregulin, administration of which rescued the elevated oral pathology of tcrδ -/- mice. Collectively, our results identify γδ T cells as critical constituents of the immuno-surveillance network that safeguard gingival tissue homeostasis.

AB - γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival γδ T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced pathology inmurine models of the oral inflammatory disease periodontitis. Alterations in bacterial communities could not account for the increased disease severity seen in γδ T cell-deficient mice. Instead, gingival γδ T cells produced the wound healing associated cytokine amphiregulin, administration of which rescued the elevated oral pathology of tcrδ -/- mice. Collectively, our results identify γδ T cells as critical constituents of the immuno-surveillance network that safeguard gingival tissue homeostasis.

KW - Amphiregulin

KW - Mucosal immunology

KW - γδ T cells

U2 - 10.1073/pnas.1802320115

DO - 10.1073/pnas.1802320115

M3 - Article

VL - 115

SP - 10738

EP - 10743

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 0027-8424

IS - 42

ER -