Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors

Research output: Contribution to journalArticle

  • External authors:
  • Shanawaz Mohammed Ghouse
  • Anastasia Polikarpova
  • Lina Muhandes
  • Jan Dudeck
  • Iliana Tantcheva-Poór
  • Karin Hartmann
  • Matthias Lesche
  • Andreas Dahl
  • Sabine Eming
  • Rayk Behrendt
  • Axel Roers

Abstract

High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.

Bibliographical metadata

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalCell Reports
Volume22
Issue number1
DOIs
Publication statusPublished - 2 Jan 2018