Age-related macular degeneration: The importance of family history as a risk factor

Research output: Contribution to journalArticle

  • External authors:
  • Humma Shahid
  • Jane C. Khan
  • Valentina Cipriani
  • Tiina Sepp
  • Baljinder K. Matharu
  • Catey Bunce
  • Simon P. Harding
  • David G. Clayton
  • Anthony T. Moore
  • John R W Yates


Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p

Bibliographical metadata

Original languageEnglish
Pages (from-to)427-431
Number of pages4
JournalBritish Journal Of Ophthalmology
Issue number3
Publication statusPublished - Mar 2012