ADH1 expression inversely correlates with CDR1 and CDR2 in Candida albicans from chronic oral candidosis in APECED (APS-I) patients

Research output: Contribution to journalArticle

  • External authors:
  • Emilia Siikala
  • Harri Saxen
  • Dominique Sanglard

Abstract

Expression of the alcohol dehydrogenase gene ADH1, which converts ethanol into carcinogenic acetaldehyde, significantly inversely correlated with the expression of CDR1 and CDR2, genes linked to azole resistance in Candida albicans isolated from chronic oral candidosis in autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED, APS-I) patients. This is a novel link between candidal two-carbon metabolism genes and azole resistance. © 2011 Federation of European Microbiological Societies.

Bibliographical metadata

Original languageEnglish
Pages (from-to)494-498
Number of pages4
JournalFEMS Yeast Research
Volume11
Issue number6
DOIs
Publication statusPublished - Sep 2011