Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.Citation formats

  • External authors:
  • Ruud C Wortel
  • Luca Incrocci
  • Floris J Pos
  • Joos V Lebesque
  • Marnix G Witte
  • Uulke A van der Heide
  • Marcel van Herk
  • Wilma D Heemsbergen

Standard

Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients. / Van Herk, Marcel; Wortel, Ruud C; Incrocci, Luca; Pos, Floris J; Lebesque, Joos V; Witte, Marnix G; van der Heide, Uulke A; van Herk, Marcel; Heemsbergen, Wilma D.

In: International journal of radiation oncology, biology, physics, Vol. 91, No. 4, 15.03.2015.

Research output: Contribution to journalArticle

Harvard

Van Herk, M, Wortel, RC, Incrocci, L, Pos, FJ, Lebesque, JV, Witte, MG, van der Heide, UA, van Herk, M & Heemsbergen, WD 2015, 'Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.', International journal of radiation oncology, biology, physics, vol. 91, no. 4. https://doi.org/10.1016/j.ijrobp.2014.12.017

APA

Van Herk, M., Wortel, R. C., Incrocci, L., Pos, F. J., Lebesque, J. V., Witte, M. G., ... Heemsbergen, W. D. (2015). Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients. International journal of radiation oncology, biology, physics, 91(4). https://doi.org/10.1016/j.ijrobp.2014.12.017

Vancouver

Van Herk M, Wortel RC, Incrocci L, Pos FJ, Lebesque JV, Witte MG et al. Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients. International journal of radiation oncology, biology, physics. 2015 Mar 15;91(4). https://doi.org/10.1016/j.ijrobp.2014.12.017

Author

Van Herk, Marcel ; Wortel, Ruud C ; Incrocci, Luca ; Pos, Floris J ; Lebesque, Joos V ; Witte, Marnix G ; van der Heide, Uulke A ; van Herk, Marcel ; Heemsbergen, Wilma D. / Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients. In: International journal of radiation oncology, biology, physics. 2015 ; Vol. 91, No. 4.

Bibtex

@article{8b9dc165cc3747b4bf4659be4cbf8e44,
title = "Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.",
abstract = "PURPOSE: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. METHODS AND MATERIALS: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. RESULTS: The median volumes receiving 5 to 75 Gy were significantly lower (all P",
author = "{Van Herk}, Marcel and Wortel, {Ruud C} and Luca Incrocci and Pos, {Floris J} and Lebesque, {Joos V} and Witte, {Marnix G} and {van der Heide}, {Uulke A} and {van Herk}, Marcel and Heemsbergen, {Wilma D}",
year = "2015",
month = "3",
day = "15",
doi = "10.1016/j.ijrobp.2014.12.017",
language = "English",
volume = "91",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.

AU - Van Herk, Marcel

AU - Wortel, Ruud C

AU - Incrocci, Luca

AU - Pos, Floris J

AU - Lebesque, Joos V

AU - Witte, Marnix G

AU - van der Heide, Uulke A

AU - van Herk, Marcel

AU - Heemsbergen, Wilma D

PY - 2015/3/15

Y1 - 2015/3/15

N2 - PURPOSE: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. METHODS AND MATERIALS: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. RESULTS: The median volumes receiving 5 to 75 Gy were significantly lower (all P

AB - PURPOSE: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. METHODS AND MATERIALS: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. RESULTS: The median volumes receiving 5 to 75 Gy were significantly lower (all P

U2 - 10.1016/j.ijrobp.2014.12.017

DO - 10.1016/j.ijrobp.2014.12.017

M3 - Article

VL - 91

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 4

ER -