Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.

Research output: Contribution to journalArticle

  • External authors:
  • Ruud C Wortel
  • Luca Incrocci
  • Floris J Pos
  • Joos V Lebesque
  • Marnix G Witte
  • Uulke A van der Heide
  • Marcel van Herk
  • Wilma D Heemsbergen

Abstract

PURPOSE: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. METHODS AND MATERIALS: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. RESULTS: The median volumes receiving 5 to 75 Gy were significantly lower (all P

Bibliographical metadata

Original languageEnglish
JournalInternational journal of radiation oncology, biology, physics
Volume91
Issue number4
DOIs
Publication statusPublished - 15 Mar 2015