Acute psychosocial stress downregulates N-Methyl-d-aspartate receptors (NMDAR) in healthy human skin

Research output: Contribution to journalLetter

  • External authors:
  • H J A Hunter
  • E Morsman
  • S K Ogden
  • L A H Zeef
  • A Hayes


Psychosocial stress impacts both healthy and diseased skin1. Whilst acute stress activates the Hypothalamic-Pituitary-Adrenal (HPA) axis, chronic stress induces suppression and impairs wound healing in humans and animals1,2. Although the underlying pathomechanisms are yet to be fully elucidated, it is clear that a better understanding of the complex relationship between neuroendocrine pathways, the immune system and the skin (the "brain-skin axis") is pivotal to the optimal management of both stress-responsive dermatoses and cutaneous wound healing. This article is protected by copyright. All rights reserved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1458-1459
JournalBritish Journal of Dermatology
Issue number6
Early online date16 Feb 2018
Publication statusPublished - Jun 2018

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