Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort StudyCitation formats

  • External authors:
  • Thomas Eade
  • Alan Pollack
  • Matthew Abramowitz
  • Felix M. Chinea
  • Linxin Guo
  • Jason Kennedy
  • Sandra Louw
  • George Hruby
  • Andrew Kneebone

Standard

Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study. / Eade, Thomas; Choudhury, Ananya; Pollack, Alan; Abramowitz, Matthew; Chinea, Felix M.; Guo, Linxin; Kennedy, Jason; Louw, Sandra; Hruby, George; Kneebone, Andrew; West, Catharine.

In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 101, No. 4, 15.07.2018, p. 957-963.

Research output: Contribution to journalArticlepeer-review

Harvard

Eade, T, Choudhury, A, Pollack, A, Abramowitz, M, Chinea, FM, Guo, L, Kennedy, J, Louw, S, Hruby, G, Kneebone, A & West, C 2018, 'Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study', International Journal of Radiation: Oncology - Biology - Physics, vol. 101, no. 4, pp. 957-963. https://doi.org/10.1016/j.ijrobp.2018.04.009

APA

Eade, T., Choudhury, A., Pollack, A., Abramowitz, M., Chinea, F. M., Guo, L., Kennedy, J., Louw, S., Hruby, G., Kneebone, A., & West, C. (2018). Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study. International Journal of Radiation: Oncology - Biology - Physics, 101(4), 957-963. https://doi.org/10.1016/j.ijrobp.2018.04.009

Vancouver

Eade T, Choudhury A, Pollack A, Abramowitz M, Chinea FM, Guo L et al. Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study. International Journal of Radiation: Oncology - Biology - Physics. 2018 Jul 15;101(4):957-963. https://doi.org/10.1016/j.ijrobp.2018.04.009

Author

Eade, Thomas ; Choudhury, Ananya ; Pollack, Alan ; Abramowitz, Matthew ; Chinea, Felix M. ; Guo, Linxin ; Kennedy, Jason ; Louw, Sandra ; Hruby, George ; Kneebone, Andrew ; West, Catharine. / Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study. In: International Journal of Radiation: Oncology - Biology - Physics. 2018 ; Vol. 101, No. 4. pp. 957-963.

Bibtex

@article{1c75e62119c3498395d7b1caf9078eb3,
title = "Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study",
abstract = "PurposeTo test the hypothesis that increased acute toxicity, measured using subdomains reflective of epithelial cell damage, will be associated with reduced late biochemical failure, as a surrogate for tumor radiosensitivity.Methods and MaterialsThe study design was retrospective, with discovery and validation cohorts involving routinely collected data. Eligible patients had prostate cancer, underwent radiation therapy with curative intent, and had acute toxicity assessed prospectively. The discovery cohort was from a single institution. Genitourinary and gastrointestinal acute toxicity related to epithelial cell damage (hematuria, dysuria, proctitis, or mucus) were related to freedom from late biochemical failure (FFBF; nadir + 2). The validation cohort was from two separate institutions.ResultsIn all, 503 patients were included in the discovery cohort and 658 patients in the validation cohort. In the validation cohort, patients with acute radiation toxicity reflecting epithelial damage had a longer FFBF on both univariate (hazard ratio [HR] 0.37; P = .004) and multivariate (HR 0.45; P = .035) analysis. The impact of acute toxicity on late FFBF seemed to be greater in patients treated with androgen deprivation (HR 0.19) than in those without (HR 0.48).ConclusionPatients reporting acute radiation toxicity reflective of epithelial cell damage during definitive radiation therapy for prostate cancer have significantly longer FFBF, consistent with an underlying genetic link between normal tissue and tumor radiosensitivity.",
author = "Thomas Eade and Ananya Choudhury and Alan Pollack and Matthew Abramowitz and Chinea, {Felix M.} and Linxin Guo and Jason Kennedy and Sandra Louw and George Hruby and Andrew Kneebone and Catharine West",
year = "2018",
month = jul,
day = "15",
doi = "10.1016/j.ijrobp.2018.04.009",
language = "English",
volume = "101",
pages = "957--963",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - Acute Epithelial Toxicity Is Prognostic for Improved Prostate Cancer Response to Radiation Therapy: A Retrospective, Multicenter, Cohort Study

AU - Eade, Thomas

AU - Choudhury, Ananya

AU - Pollack, Alan

AU - Abramowitz, Matthew

AU - Chinea, Felix M.

AU - Guo, Linxin

AU - Kennedy, Jason

AU - Louw, Sandra

AU - Hruby, George

AU - Kneebone, Andrew

AU - West, Catharine

PY - 2018/7/15

Y1 - 2018/7/15

N2 - PurposeTo test the hypothesis that increased acute toxicity, measured using subdomains reflective of epithelial cell damage, will be associated with reduced late biochemical failure, as a surrogate for tumor radiosensitivity.Methods and MaterialsThe study design was retrospective, with discovery and validation cohorts involving routinely collected data. Eligible patients had prostate cancer, underwent radiation therapy with curative intent, and had acute toxicity assessed prospectively. The discovery cohort was from a single institution. Genitourinary and gastrointestinal acute toxicity related to epithelial cell damage (hematuria, dysuria, proctitis, or mucus) were related to freedom from late biochemical failure (FFBF; nadir + 2). The validation cohort was from two separate institutions.ResultsIn all, 503 patients were included in the discovery cohort and 658 patients in the validation cohort. In the validation cohort, patients with acute radiation toxicity reflecting epithelial damage had a longer FFBF on both univariate (hazard ratio [HR] 0.37; P = .004) and multivariate (HR 0.45; P = .035) analysis. The impact of acute toxicity on late FFBF seemed to be greater in patients treated with androgen deprivation (HR 0.19) than in those without (HR 0.48).ConclusionPatients reporting acute radiation toxicity reflective of epithelial cell damage during definitive radiation therapy for prostate cancer have significantly longer FFBF, consistent with an underlying genetic link between normal tissue and tumor radiosensitivity.

AB - PurposeTo test the hypothesis that increased acute toxicity, measured using subdomains reflective of epithelial cell damage, will be associated with reduced late biochemical failure, as a surrogate for tumor radiosensitivity.Methods and MaterialsThe study design was retrospective, with discovery and validation cohorts involving routinely collected data. Eligible patients had prostate cancer, underwent radiation therapy with curative intent, and had acute toxicity assessed prospectively. The discovery cohort was from a single institution. Genitourinary and gastrointestinal acute toxicity related to epithelial cell damage (hematuria, dysuria, proctitis, or mucus) were related to freedom from late biochemical failure (FFBF; nadir + 2). The validation cohort was from two separate institutions.ResultsIn all, 503 patients were included in the discovery cohort and 658 patients in the validation cohort. In the validation cohort, patients with acute radiation toxicity reflecting epithelial damage had a longer FFBF on both univariate (hazard ratio [HR] 0.37; P = .004) and multivariate (HR 0.45; P = .035) analysis. The impact of acute toxicity on late FFBF seemed to be greater in patients treated with androgen deprivation (HR 0.19) than in those without (HR 0.48).ConclusionPatients reporting acute radiation toxicity reflective of epithelial cell damage during definitive radiation therapy for prostate cancer have significantly longer FFBF, consistent with an underlying genetic link between normal tissue and tumor radiosensitivity.

U2 - 10.1016/j.ijrobp.2018.04.009

DO - 10.1016/j.ijrobp.2018.04.009

M3 - Article

VL - 101

SP - 957

EP - 963

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 4

ER -